PMID: 10468734Sep 1, 1999Paper

Carbachol-induced sustained tonic contraction of rat detrusor muscle

BJU International
S J OhH Choi

Abstract

To investigate the underlying contractile mechanism of the sustained tonic contraction (SuTC) induced by repetitive carbachol application in rat detrusor muscles. Longitudinal muscle strips with no mucosa were obtained from the anterior wall of the urinary bladder in 12-week-old Sprague-Dawley rats. Carbachol (5 micromol/L) was applied repetitively to induce SuTC. The carbachol-induced SuTC was assessed in the presence of various Ca2+-channel blockers and drugs affecting intracellular Ca2+ concentration. The first application of carbachol elicited a large phasic contraction followed by a tonic contraction (TC); the carbachol-induced contraction was completely reversed by washing out the solution. However, the initial phasic contraction was not reproduced after a second or further application of carbachol. There was consistently only a SuTC with no phasic contraction. The amplitude of the SuTC was 85% of the TC induced by the first carbachol application. The application of atropine (1 micromol/L) to the bath completely blocked SuTC. The carbachol-induced SuTC was insensitive to nicardipine (5 micromol/L) and extracellular polyvalent cations (1 mmol/L, La3+, Co2+, Cd2+, Ni2+ ). Moreover, a similar SuTC was induced even after the ...Continue Reading

References

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Nov 1, 1989·British Journal of Pharmacology·C A MaggiA Meli
Oct 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·W UchidaT Takenada
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Citations

Sep 24, 2005·American Journal of Physiology. Cell Physiology·Kozo MorimuraYuji Imaizumi
May 24, 2001·The Journal of Urology·S J OhH Choi
Apr 28, 2017·American Journal of Physiology. Renal Physiology·Young Jae ImKwanjin Park
Aug 5, 2004·BJU International·Rozbeh Faramarzi-RoquesJean-Pierre Mazat
Nov 5, 2003·Neurourology and Urodynamics·Bruno LorenziAlison F Brading

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