Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study

Journal of Biochemical and Molecular Toxicology
Alicja UrbaniakTimothy C Chambers

Abstract

Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchicine, has been tested against two types of primary cancer cells. These included acute lymphoblastic leukemia (ALL) and human breast cancer (BC) derived from two different tumor subtypes, ER+ invasive ductal carcinoma grade III (IDCG3) and metastatic carcinoma (MC). Four novel COL derivatives showed higher anti-proliferative activity than COL (IC50  = 8.6 nM) towards primary ALL cells in cell viability assays (IC50 range of 1.1-6.4 nM), and several were more potent towards primary IDCG3 (IC50 range of 0.1 to 10.3 nM) or MC (IC50 range of 2.3-9.1 nM) compared to COL (IC50 of 11.1 and 11.7 nM, respectively). In addition, several derivatives were selectively active toward primary breast cancer cells compared to normal breast epithelial cells. The most promising derivatives were subsequently tested against the NCI panel of 60 human cancer cell lines and seven derivatives were more potent than COL against leukemia, non-small-cell lung, colon, CNS and prostate cancers. Finally, COL a...Continue Reading

References

Oct 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·P C BartelsJ B Soons
Jan 1, 1983·Investigational New Drugs·J K WeickE J Van Slyck
Apr 30, 1996·Annals of the New York Academy of Sciences·R Leake
Mar 13, 2003·Breast Cancer Research : BCR·Sarah E BurdallValerie Speirs
Sep 10, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Patrice J Morin
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Feb 4, 2006·Current Treatment Options in Oncology·Robert A Nagourney
Sep 23, 2006·Nature Reviews. Cancer·Robert H Shoemaker
Apr 28, 2007·Medicinal Research Reviews·Bhabatarak BhattacharyyaMithu Banerjee
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nkechi IchiteMandip Singh
Oct 28, 2009·International Journal of Cancer. Journal International Du Cancer·Wilhelm G DirksHiroshi Mizusawa
Dec 23, 2011·The American Journal of Pathology·Xuefeng LiuRichard Schlegel
Jul 21, 2012·Pharmaceutical Research·Yan LuDuane D Miller
Jan 3, 2015·The American Journal of Medicine·Anastasia SlobodnickSvetlana Krasnokutsky
Oct 19, 2016·Nature Reviews. Clinical Oncology·Giampaolo BianchiniLuca Gianni
Aug 3, 2017·International Journal of Molecular Sciences·Ivana SpasevskaJack A Tuszynski
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alicja UrbaniakTimothy C Chambers
Jul 20, 2018·European Journal of Medicinal Chemistry·Michał AntoszczakDaniel Strand
Sep 25, 2018·Bioorganic Chemistry·Urszula MajcherAdam Huczyński
Sep 5, 2019·Chemical Biology & Drug Design·Greta KlejborowskaAdam Huczyński

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Citations

Jun 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alicja UrbaniakAngus M MacNicol

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