Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia.

Archives of Pharmacal Research
Nagla A El-SherbeenySawsan A Zaitone

Abstract

This work tested the role of carbamazepine in alleviating alloxan-induced diabetic neuropathy and the enhancement of spinal plasticity. Mice were randomized into four groups: normal, control, carbamazepine (25-mg/kg) and carbamazepine (50-mg/kg). Nine weeks after induction of diabetes, symptoms of neuropathy were confirmed and carbamazepine (or vehicle) was given every other day for five weeks. After completing the treatment period, mice were sacrificed and the pathologic features in the spinal cord and the sciatic nerves were determined. The spinal cords were evaluated for synaptic plasticity (growth associated protein-43, GAP43), microglia cell expression (by CD11b) and astrocyte expression (glial fibrillary acidic protein, GFAP). Further, sciatic nerve expression of Nav1.5 was measured. Results revealed that carbamazepine 50 mg/kg prolonged the withdrawal threshold of von-Frey filaments and increased the hot plate jumping time. Carbamazepine improved the histopathologic pictures of the sciatic nerves and spinal cords. Spinal cord of carbamazepine-treated groups had enhanced expression of GAP43 but lower content of CD11b and GFAP. Furthermore, specimens from the sciatic nerve indicated low expression of Nav1.5. In conclusion,...Continue Reading

References

Jan 1, 1993·Journal of Neurocytology·R CurtisG P Wilkin
Jul 15, 1999·Nature Neuroscience·H A HartmannJ L Noebels
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 13, 2002·European Journal of Pain : EJP·Troels S Jensen
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y OuG Farrugia
Oct 24, 2002·Brain Research. Molecular Brain Research·M RenganathanS G Waxman
Jun 1, 2005·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K-M HaslbeckD Heuss
Mar 25, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zainab H AfsariE Abd-El-Basset
May 24, 2008·European Journal of Pain : EJP·Andreas HaldAnne-Marie Heegaard
Oct 29, 2008·The Journal of Thoracic and Cardiovascular Surgery·Mustafa SirlakUmit Ozyurda
Apr 4, 2009·Physiological Reviews·Jürgen Sandkühler
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Irina G Obrosova
Oct 13, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sulayman D Dib-HajjStephen G Waxman
Nov 4, 2009·Biochimica Et Biophysica Acta·Yoko KikumotoHirofumi Makino
Feb 12, 2010·Brain : a Journal of Neurology·Joel A BlackStephen G Waxman
Jul 27, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Min Liu, John N Wood
Oct 25, 2011·Indian Journal of Pharmacology·Bharti ChogtuP Himabindu
Sep 1, 2012·British Journal of Anaesthesia·T S HahmJ M Yu
Mar 19, 2013·European Journal of Pharmacology·Joanna MikaBarbara Przewlocka
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna Letizia Allegra MascaroFrancesco S Pavone
Nov 13, 2013·The Cochrane Database of Systematic Reviews·Philip J WiffenEija A Kalso
Apr 11, 2014·The Cochrane Database of Systematic Reviews·Philip J WiffenEija A Kalso
May 30, 2014·Journal of Neurophysiology·Christopher T FrenzVincent E Dionne
Jul 10, 2014·JAMA : the Journal of the American Medical Association·Andrew MooreEija Kalso
Aug 19, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Harry J GouldDennis Paul
Oct 31, 2012·Clinical Pharmacology & Biopharmaceutics·Alicja WoronowiczY Peng Loh
Jun 5, 2015·Current Opinion in Pharmacology·Kevin Kwong, Michael J Carr
Jan 28, 2016·Journal of Diabetes Investigation·Makoto Tsuda
Feb 27, 2016·Glia·Laura W PappalardoStephen G Waxman
Sep 2, 2016·Current Protocols in Mouse Biology·Corinne G JolivaltNigel A Calcutt

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