PMID: 8608437Mar 1, 1995Paper

Carbamazepine-exacerbated epilepsy with multifocal shifting independent epileptiform discharges on electroencephalogram: a case report

Psychiatry and Clinical Neurosciences
M KimuraN Suzuki

Abstract

A 7 year old girl with epilepsy and spastic quadriplegia secondary to an episode of status epilepticus at 4 months of age is reported. At the age of 6 years, she began to experience increased generalized myoclonic and tonic seizures during treatment with carbamazepine (CBZ) 200 mg/day and clonazepam 1.5 mg/day. When the CBZ was increased to 400 mg/day, the seizures increased dramatically in frequency. Following discontinuation of CBZ, the seizure frequency decreased to a level less than that prior to starting CBZ. Serial electroencephalograms displayed multifocal independent epileptiform discharges (MIED) characterized by shifting localization, which could be one of the risk factors for exacerbation by CBZ. In this case MIED may indicate widespread rather than localized cerebral dysfunction.

References

Nov 1, 1986·Pediatric Neurology·C S HornD L Hurst
Oct 10, 1985·The New England Journal of Medicine·O C Snead, L C Hosey

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Citations

May 13, 1998·Epilepsia·E PeruccaO Dulac
Nov 27, 2002·Clinical EEG (electroencephalography)·M Gansaeuer, T M Alsaadi

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