Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype

BMJ Case Reports
Francis CapuleCatherine Lynn Silao

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a strong relationship between the HLA-B*1502 allele and carbamazepine-induced SJS and TEN in different Southeast Asian populations. Here, we report a case of Filipino with SJS/TEN overlap probably induced by carbamazepine. The condition was treated with hydrocortisone followed by prednisone. The HLA-B*1502 allele was not found in this case. The patient tested positive for the HLA-B75 serotype, suggesting that carbamazepine-induced SJS/TEN may be serotype specific. Establishing the genotype before initiation of the drug may be advantageous for some patients and will aid physicians in determining the optimal drug therapy. Prevention of adverse drug reactions (ADR) may be done if pharmacists and other healthcare professionals work as a multidisciplinary ADR team to ensure that safe medication practices are realised.

References

Feb 15, 1995·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Mar 16, 2006·Pharmacogenetics and Genomics·Shuen-Iu HungYuan-Tsong Chen
Jan 5, 2007·Acta Psychiatrica Scandinavica·L A SmithD Taylor
Jan 15, 2008·Pharmacogenetics and Genomics·Christine LonjouUNKNOWN RegiSCAR study group
Nov 17, 2009·Indian Journal of Dermatology, Venereology and Leprology·Timir Y MehtaRamesh K Goyal
Mar 15, 2011·Seizure : the Journal of the British Epilepsy Association·Qian WangHong-xuan Wang
Mar 25, 2011·The New England Journal of Medicine·Pei ChenUNKNOWN Taiwan SJS Consortium
Jun 17, 2011·Pain Practice : the Official Journal of World Institute of Pain·Kongkiat KulkantrakornPaskorn Sritipsukho
Sep 16, 2011·Epilepsy Research·Sae-Hoon KimUNKNOWN Adverse Drug Reaction Research Group in Korea
Apr 17, 2013·Clinical Pharmacology and Therapeutics·U AmstutzUNKNOWN CPNDS Consortium
May 8, 2013·International Journal of Clinical Pharmacy·Somsak TiamkaoSuthipun Jitpimolmard
May 6, 2015·Asia Pacific Allergy·Dinh Van NguyenSheryl van Nunen
Jun 18, 2015·Human Genomics·Konstantinos MitropoulosGeorge P Patrinos
Mar 31, 2016·Pharmacogenomics·Chonlaphat Sukasem, Wasun Chantratita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.