PMID: 6968264Oct 1, 1980Paper

Carbamazepine intoxication due to triacetyloleandomycin administration in epileptic patients

Epilepsia
E MesdjianJ Roger

Abstract

In 17 epileptics receiving carbamazepine (CBZ) alone or in combination with other anticonvulsant drugs, administration of triacetyloleandomycin (Tri A) led to an acute and unexpected intoxication (drowsiness, nausea, vomiting, and dizziness). Similar symptoms occurred again in 3 patients after Tri A was administered a second time. The same toxic manifestations were observed in two patients receiving CBZ and erythromycin. A rapid increase in plasma levels of CBZ occurred after institution of Tri A therapy in 6 patients, the CBZ levels quickly returning to normal after withdrawal of Tri A. Thus, it is suggested that the observed intoxication is due to the simultaneous administration of CBZ and Tri A (or erythromycin). The possible role of hepatic dysfunction in this syndrome of intoxication is discussed. Furthermore, the intoxication may be at least partially related to serum electrolyte disturbances, as suggested by one case in which obvious signs of water intoxication were detected. The severity and frequency of intoxication should lead to proscribing Tri A or other macrolide antibiotics in patients receiving CBZ.

References

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·G VinçonP Loiseau
Aug 15, 2000·Epilepsy Research·E PeruccaT Tomson
Nov 18, 1982·The New England Journal of Medicine·J M WrightV P Sweeney
Sep 1, 1989·The Japanese Journal of Psychiatry and Neurology·T TagawaH Yabuuchi
Jan 1, 1987·Epilepsia·W E Dodson
May 21, 1998·Epilepsia·R GuerriniP Genton
Apr 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·P N PatsalosG Smith
Jul 18, 2006·Drug Metabolism and Drug Interactions·Markus FridénVrinda N Nandi
Apr 1, 1988·Veterinary and Human Toxicology·R D Kimbrough
Dec 1, 1995·Journal of Clinical Psychopharmacology·T A KetterA M Callahan
Feb 25, 2009·Thérapie·Philippe GélissePierre Genton
Dec 1, 1987·British Journal of Clinical Pharmacology·N BarzaghiE Perucca
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L K Pershing, M R Franklin
May 29, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Olivier Pauwels
Mar 1, 1989·Medical Toxicology and Adverse Drug Experience·L DurelliR Cavallo
Nov 1, 1989·DICP : the Annals of Pharmacotherapy·R A Mitsch

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