Carbamazepine versus valproate monotherapy for epilepsy

The Cochrane Database of Systematic Reviews
A G MarsonD W Chadwick

Abstract

Carbamazepine and valproate are drugs of first choice for epilepsy. Despite the lack of hard evidence from individual randomized controlled trials, there is strong clinical belief that valproate is the drug of choice for generalized epilepsies and carbamazepine for partial epilepsies. To overview the best evidence comparing carbamazepine and valproate monotherapy Our search strategy included: (a) MEDLINE 1966-99, (b) The Cochrane Library 1999 issue 4, (c) The trial register of the Cochrane Epilepsy Group (d) the pharmaceutical industry. Randomized controlled trials comparing carbamazepine and valproate monotherapy for epilepsy. This was an individual patient data review. Outcome measures were time to withdrawal of allocated treatment, time to 12 month remission, and time to first seizure post randomization. Data were analysed using the stratified Logrank test with results expressed as hazard ratios (HR) (95% CI), where HR>1 indicates an event is more likely on valproate. A test for an interaction between treatment and epilepsy type (partial versus generalized) was also undertaken. Results Data were available for 1265 patients from five trials, representing 85% of the patients recruited into the eight trials that met our inclusi...Continue Reading

References

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Nov 10, 2005·Seizure : the Journal of the British Epilepsy Association·Bernhard J SteinhoffUNKNOWN LAM-SAFE Study Group

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Citations

Dec 4, 2010·BMJ : British Medical Journal·Janneke JentinkUNKNOWN EUROCAT Antiepileptic Study Working Group
Oct 27, 2009·Neurologic Clinics·Linda J Stephen, Martin J Brodie
Jul 1, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Dec 7, 2016·The Cochrane Database of Systematic Reviews·Sarah J NolanAnthony G Marson
Jun 29, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Dec 20, 2013·The Cochrane Database of Systematic Reviews·Katie CarmichaelAnthony G Marson
Aug 10, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittCatrin Tudur Smith
Jun 25, 2019·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Jul 19, 2019·The Cochrane Database of Systematic Reviews·Sarah J NevittCatrin Tudur Smith
Oct 13, 2019·Metabolic Brain Disease·Asmat Ullah KhanSaeed Ahmad
Oct 26, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittCatrin Tudur Smith
Dec 16, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
Oct 24, 2018·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson
May 7, 2016·The Cochrane Database of Systematic Reviews·Maurizio A LeoneEttore Beghi
Dec 10, 2016·The Cochrane Database of Systematic Reviews·Graham PowellAnthony G Marson
Jul 28, 2020·The Cochrane Database of Systematic Reviews·Francesco BrigoNicola Luigi Bragazzi
Apr 13, 2012·Journal of Medical Economics·Janneke JentinkMaarten J Postma
Nov 15, 2016·The Cochrane Database of Systematic Reviews·Sarah J NolanAnthony G Marson
Feb 28, 2017·The Cochrane Database of Systematic Reviews·Sarah J NevittCatrin Tudur Smith
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Sarah J NolanCatrin Tudur Smith
Oct 20, 2018·The Cochrane Database of Systematic Reviews·Francesco BrigoNicola Luigi Bragazzi
Aug 20, 2019·The Cochrane Database of Systematic Reviews·Sarah J NevittAnthony G Marson

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