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Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N- nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Biochemical Pharmacology

Mar 21, 1997

U VanhoeferY M Rustum

Abstract

Intracellular glutathione (GSH) concentrations have been implicated recently as a regulatory determinant of multidrug resistance protein (MRP)-mediated drug efflux. Inhibition of glutathione reductase (GR) activity of N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU) has been employed extensi...read more

Mentioned in this Paper

Doxorubicin
Tumor Cells, Uncertain Whether Benign or Malignant
Northern Blotting
Derivatives
Protoplasm
Glutamate-Cysteine Ligase
Buthionine Sulfoximine
Antineoplastic Agents, Alkylating
Glutathione Measurement
Drug Efflux
Paper Details
References
  • References9
  • Citations15
1
  • References9
  • Citations15
12

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Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N- nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Biochemical Pharmacology

Mar 21, 1997

U VanhoeferY M Rustum

PMID: 9113101

DOI: 10.1016/s0006-2952(97)00010-5

Abstract

Intracellular glutathione (GSH) concentrations have been implicated recently as a regulatory determinant of multidrug resistance protein (MRP)-mediated drug efflux. Inhibition of glutathione reductase (GR) activity of N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU) has been employed extensi...read more

Mentioned in this Paper

Doxorubicin
Tumor Cells, Uncertain Whether Benign or Malignant
Northern Blotting
Derivatives
Protoplasm
Glutamate-Cysteine Ligase
Buthionine Sulfoximine
Antineoplastic Agents, Alkylating
Glutathione Measurement
Drug Efflux

Similar Papers Found In These Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Drug Efflux Transporters

Drug efflux transporters, such as P-glycoprotein (Pgp), multidrug resistance proteins (MRPs) or organic anion transporting polypeptides (OATPs), transport drug molecules out of the cells. Discover the latest research on drug efflux transporters here.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)

Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)March 1, 1997
S EgyháziU Ringborg
Paper Details
References
  • References9
  • Citations15
1
  • References9
  • Citations15
12
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