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Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N- nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Biochemical Pharmacology

Mar 21, 1997

Udo VanhoeferYoucef M Rustum

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Abstract

Intracellular glutathione (GSH) concentrations have been implicated recently as a regulatory determinant of multidrug resistance protein (MRP)-mediated drug efflux. Inhibition of glutathione reductase (GR) activity of N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU) has been employed extensi...read more

Mentioned in this Paper

Gene Expression
Multi-Drug Resistance
Glutathione Reductase
Tumor Cells, Cultured
GCLM protein, human
Oxidation-Reduction
Retention Within Cell
Antineoplastic Agents, Alkylating
Northern Blotting
Metabolic Inhibition
Paper Details
References
  • References9
  • Citations14
1
  • References9
  • Citations14
12

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Carbamoylation of glutathione reductase by N,N-bis(2-chloroethyl)-N- nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Biochemical Pharmacology

Mar 21, 1997

Udo VanhoeferYoucef M Rustum

PMID: 9113101

DOI: 10.1016/s0006-2952(97)00010-5

Abstract

Intracellular glutathione (GSH) concentrations have been implicated recently as a regulatory determinant of multidrug resistance protein (MRP)-mediated drug efflux. Inhibition of glutathione reductase (GR) activity of N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU) has been employed extensi...read more

Mentioned in this Paper

Gene Expression
Multi-Drug Resistance
Glutathione Reductase
Tumor Cells, Cultured
GCLM protein, human

Related Papers

Paper Details
References
  • References9
  • Citations14
1
  • References9
  • Citations14
12

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