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Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate

Chemical Research in Toxicology

Jul 1, 1991

P G PearsonT A Baillie

PMID: 1912331

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Abstract

The reactivity toward peptides and proteins of S-(N-methylcarbamoyl)glutathione (SMG), the glutathione conjugate of methyl isocyanate, and the corresponding cysteine adduct, S-(N-methylcarbamoyl)cysteine (SMC), was investigated with the aid of in vitro model systems. Incubation of SMC o...read more

Mentioned in this Paper

Isocyanates
Covalent Interaction
Carbamates
Thioester
Analog
ALB
Tromethamine
Sulfhydryl Compounds
Tandem Mass Spectrometry
Glutathione Measurement
Paper Details
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S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate

Biochemical and Biophysical Research CommunicationsJanuary 15, 1990
P G PearsonT A Baillie
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Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate

Chemical Research in Toxicology

Jul 1, 1991

P G PearsonT A Baillie

PMID: 1912331

DOI:

Abstract

The reactivity toward peptides and proteins of S-(N-methylcarbamoyl)glutathione (SMG), the glutathione conjugate of methyl isocyanate, and the corresponding cysteine adduct, S-(N-methylcarbamoyl)cysteine (SMC), was investigated with the aid of in vitro model systems. Incubation of SMC o...read more

Mentioned in this Paper

Isocyanates
Covalent Interaction
Carbamates
Thioester
Analog
ALB
Tromethamine
Sulfhydryl Compounds
Tandem Mass Spectrometry
Glutathione Measurement

Feeds With Similar Papers

Neural Circuits & Oxytocin

Oxytocin has been suggested to be involved in synaptic plasticity and adaptively modifying neural circuits for social interactions such as conspecific recognition, pair bonding, and maternal care. Find the latest research on neuronal circuits and oxytocin here.

Neuropeptides

There are >50 peptides released by neurons that function as neuromodulators, neurotransmitters, neurohormones, and hormones. Here is the latest research on the systemic function of neuropeptides in the body.

Related Papers

Biochemical and Biophysical Research Communications

S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate

Biochemical and Biophysical Research CommunicationsJanuary 15, 1990
P G PearsonT A Baillie
Paper Details
References
  • References
  • Citations20
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations20
12

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