PMID: 6982902Oct 1, 1982Paper

Carbamycholine modulation of E-rosette formation: identification of nicotinic acetylcholine receptors on a subpopulation of human T lymphocytes

Journal of Clinical Immunology
Y MizunoE W Gelfand

Abstract

We previously suggested that a population of T-suppressor cells carries acetylcholine receptors which may be involved in the regulation of the immune response. To identify cholinergic receptors on human T lymphocytes, we investigated the effects of carbachol, a cholinergic agonist, on E-rosette formation. Preincubation of normal human peripheral blood cells with carbachol resulted in a 30-40% reduction in numbers of E rosette-forming cells. Carbachol-induced inhibition of E-rosette formation was dose-dependent, temperature dependent, and reversible. The drug effects appeared to be mediated through a nicotinic acetylcholine receptor since d-tubocurarine (but not atropine) abrogated its activity. The expression of nicotinic receptors on a subset of human T cells may play an important role in the pathogenesis of certain diseases such as myasthenia gravis.

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Citations

Feb 21, 2013·Alcoholism, Clinical and Experimental Research·Jeffrey D RitzenthalerJesse Roman
Jan 1, 1987·Annals of the New York Academy of Sciences·S Berrih-AkninJ F Bach
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Sarah V CulpittPeter J Barnes
Sep 15, 2020·Frontiers in Molecular Neuroscience·Martin KrennFritz Zimprich
Jun 24, 2000·Proceedings of the Society for Experimental Biology and Medicine·N HallquistS Pross

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