PMID: 5917090Oct 21, 1966

Carbamylation and binding constants for the inhibition of acetylcholinesterase by physostigmine (eserine)

A R MAIN, F L Hastings


The kinetic treatment and experimental procedures which have been used to evaluate the binding and phosphorylation rate constants of organophos phate inhibitors were applied to the carbamate inhibitor eserine. The binding constant K(I)carbamylation rate constant k(2e)for the inhibition of acetyl cholinesterase by eserine were successfully evaluated.


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Feb 1, 1979·Bulletin of Environmental Contamination and Toxicology·Y A Abdel-AalA H El-Sebae
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·N A Mahmood, W W Carmichael
Feb 14, 1972·Biochimica Et Biophysica Acta·D F Parsons, J R Subjeck
Oct 1, 1971·Biochimica Et Biophysica Acta·L C Post
Jan 1, 1969·Annals of the New York Academy of Sciences·R D O'Brien
Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G BlomqvistL Di Giamberardino
Sep 9, 2011·The Journal of Pharmacy and Pharmacology·Dorothea KaufmannMichael Wink
Jan 16, 2003·Biochemical Pharmacology·M BartoliniVincenza Andrisano
Jun 1, 1987·British Journal of Pharmacology·A Bottoncetti, A Galli
Jan 1, 1987·British Journal of Pharmacology·G M FrigoM Marcoli
May 1, 1985·Biochemical Pharmacology·A Galli
Jul 15, 1976·Biochemical Pharmacology·Y S MohammedM M Mahfouz
Mar 8, 2012·ACS Medicinal Chemistry Letters·Angela RampaVincenzo Di Marzo
Sep 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dorothea KaufmannMichael Wink
Sep 7, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Daniela De VitaLuigi Scipione
Sep 20, 1977·Biochemistry·S OtienoE A Barnard
Feb 1, 1981·International Journal of Peptide and Protein Research·R Narayanan, P Balaram
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Acharya BalkrishnaAnurag Varshney
Dec 1, 1968·The Journal of Pharmacy and Pharmacology·B Robinson, J B Robinson

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