Carbetocin compared to oxytocin in emergency cesarean section: a randomized trial

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nuguelis RazaliPeng Chiong Tan

Abstract

To evaluate the uterotonic effect of carbetocin compared with oxytocin in emergency cesarean delivery. Participants were randomized to intravenous bolus injection of 100mcg carbetocin or 10IU oxytocin after cesarean delivery of the baby. The primary outcome is any additional uterotonic which may be administered by the blinded provider for perceived inadequate uterine tone with or without hemorrhage in the first 24hours after delivery. Secondary outcomes include operating time, perioperative blood loss, change in hemoglobin and hematocrit levels, blood transfusion and reoperation for postpartum hemorrhage. Additional uterotonic rates were 107/276 (38.8%) vs. 155/271 (57.2%) [RR 0.68 95% CI 0.57-0.81 p<0.001; NNTb 6 95% CI 3.8-9.8], mean operating time 45.9±16.0 vs. 44.5±13.1minutes p=0.26, mean blood loss 458±258 vs. 446±281ml p=0.6, severe postpartum hemorrhage (≥1000ml) rates 15/276 (5.4%) vs. 10/271 (3.7%) p=0.33 and blood transfusion rates 6/276 (2.2%) vs. 10/271 (3.7%); p=0.30 for carbetocin and oxytocin arms respectively. There was only one case of re-operation (oxytocin arm). In the cases that needed additional uterotonic 98% (257/262) was started intraoperatively and in 89% (234/262) the only additional uterotonic admini...Continue Reading

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Citations

Nov 7, 2016·International Journal of Obstetric Anesthesia·L S MeshykhiD N Lucas
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Nov 10, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jemma WohlingGustaaf Dekker
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Sep 21, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Erkan KalafatAsma Khalil
Oct 14, 2017·The Journal of Obstetrics and Gynaecology Research·Hian Yan VoonHaris N Suharjono
Nov 3, 2016·Current Opinion in Obstetrics & Gynecology·Jennifer E JardineUNKNOWN C-SAFETY
Sep 18, 2021·American Journal of Obstetrics and Gynecology·Danish JafferDavid Thomas Monks

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