Carbetocin for preventing postpartum haemorrhage

The Cochrane Database of Systematic Reviews
Lin-Lin SuMiny Samuel

Abstract

Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH. Syntometrine is more effective than oxytocin but is associated with more side effects. Carbetocin, a long-acting oxytocin agonist, appears to be a promising agent for the prevention of PPH. To determine if the use of oxytocin agonist is as effective as conventional uterotonic agents for the prevention of PPH, and assess the best routes of administration and optimal doses of oxytocin agonist. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (1 March 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 1 of 4), MEDLINE (1966 to 1 March 2011) and EMBASE (1974 to 1 March 2011). We checked references of articles and communicated with authors and pharmaceutical industry contacts. Randomised controlled trials which compared oxytocin agonist (carbetocin) with other uterotonic agents or with placebo or no treatment for the prevention of PPH. Two review authors independently assessed trials for inclusion, assessed risk of bias and extracted data. We inclu...Continue Reading

Citations

Jan 15, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Helen A van der NelsonAnthony J Hatswell
Jan 4, 2017·Taiwanese Journal of Obstetrics & Gynecology·Chih-Yao ChenHsin-Yi Huang
Mar 21, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Yasmin LuniPadma Eedarapalli
Jul 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Laura SotilloJose Luis Bartha
Feb 14, 2014·The Cochrane Database of Systematic Reviews·Hatem A MousaZarko Alfirevic
Mar 2, 2019·Health Technology Assessment : HTA·Ioannis GallosArri Coomarasamy
Jun 28, 2018·Reproductive Health·Fiona J TheunissenYeshita V Pujar
Nov 28, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mubeen KhanJose C A Carvalho
Apr 11, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nhathien Nguyen-LuMrinalini Balki
Feb 15, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wen-Wei HsuChien-Nan Lee
Aug 10, 2021·Health Care for Women International·Reyhan ErkayaKıymet Yeşilçiçek Çalik

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