Carbofuran induced block of compensatory ovarian growth in hemicastrated albino mice

Toxicology
P N Baligar, B B Kaliwal

Abstract

Carbofuran, a systemic N-methyl carbamate pesticide was orally administered at doses of 0.4, 0.7, 1 and 1.3 mg/(kg day) to normal hemicastrated (HC) mice for 15 consecutive days to investigate the effects on compensatory ovarian growth. Sham-operated and hemicastrated control mice were administered a similar quantity of olive oil. The vaginal smear and body weight of the mice were recorded daily and mice were sacrificed on day 16. The results revealed that the HC control mice showed 54.58% increase in the ovary weight of the remaining left ovary and many follicles, corpora lutea and showed normal estrous cycle as compared to Sham-operated control mice. The remaining left ovaries of the mice treated with 1.3 mg carbofuran showed 0.82% increase in the ovary weight and significant decrease in the number of developing follicles, corpora lutea, increase in many atretic follicles, the estrous cycle and its phases were affected when compared to HC control mice. In HC mice treated with 1 mg/(kg day) carbofuran resulted in 12.63% increase in the ovary weight and showed significant decrease in follicles, corpora lutea and many increased atretic follicles. The estrous cycle was affected with significant decrease in estrus phase and increa...Continue Reading

References

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Nov 5, 1997·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B BolonJ J Heindel
Dec 28, 2002·Industrial Health·Prakash N Baligar, Basappa B Kaliwal
Jun 1, 1964·The Journal of Endocrinology·D L PETERSONR C JONES

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Citations

Feb 16, 2011·Toxicology Mechanisms and Methods·Eva RollerovaMiroslava Urbancikova
Jan 8, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ozgur CinarAlp Can

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