Carbohydrate-antigen-125 levels predict hospital stay duration and adverse events at long-term follow-up in Takotsubo cardiomyopathy

Internal and Emergency Medicine
Francesco SantoroNatale Daniele Brunetti

Abstract

The aim of this study is to evaluate the possible role of carbohydrate-antigen(CA)-125 as prognostic marker at short- and long-term follow-up, in subjects with Takotsubo cardiomyopathy (TTC). Sixty-three consecutive subjects with TTC were enrolled in the study and followed for a median 139 days. Circulating levels of CA-125, NT-proBNP, and left ventricular ejection fraction (LVEF) were evaluated at admission. Duration of hospital stay, incidence of death, re-hospitalization and recurrence of TTC during follow-up were recorded. The mean hospital stay was 8.3 days, adverse events occurred during follow up in 17 % of cases. CA-125 levels at admission are inversely related to LVEF (r -0.30, p < 0.05) and directly related to hospital stay (r 0.29, p < 0.05). CA-125 levels at admission are higher in subjects with adverse events at follow-up (88.9 ± 200.0 vs 20.9 ± 30.0 U/mL, p < 0.05). Rates of incidence of adverse events are proportionally increased with CA-125 tertiles (0, 6, 11 % respectively, p for trend <0.01), at survival analysis (Log Rank p < 0.05) and after correction for age, gender, LVEF and NT-proBNP levels in multivariable Cox analysis (p < 0.05). CA-125 levels <10 U/ml are predictors of adverse events at follow up with ...Continue Reading

References

Oct 15, 1991·Annals of Internal Medicine·S E Bates
Oct 13, 1983·The New England Journal of Medicine·R C BastR C Knapp
Jul 31, 1998·The New England Journal of Medicine·E R LevinW K Samson
Jun 1, 2000·Human Reproduction·M EpineyP Bischof
Jul 14, 2001·Journal of the American College of Cardiology·K TsuchihashiUNKNOWN Angina Pectoris-Myocardial Infarction Investigations in Japan
Aug 20, 2004·QJM : Monthly Journal of the Association of Physicians·Y J AkashiF Miyake
May 27, 2005·European Journal of Heart Failure·Ercan VarolFeridun Kosar
Jul 22, 2006·Journal of Cardiovascular Medicine·Pompilio FaggianoLivio Dei Cas
Mar 19, 2011·Journal of the American College of Cardiology·Malini MadhavanAbhiram Prasad
Aug 30, 2011·The American Journal of Cardiology·Thanh Ha NguyenJohn D Horowitz
Sep 15, 2011·European Journal of Clinical Investigation·Luisa De GennaroMatteo Di Biase
Jun 28, 2012·Cardiology in Review·Enrico VizzardiLivio Dei Cas
May 1, 2013·International Journal of Cardiology·Riccardo IevaNatale Daniele Brunetti
Oct 15, 2013·Cardiovascular Therapeutics·Francesco SantoroNatale Daniele Brunetti
Dec 18, 2013·Journal of Cardiac Failure·Mandeep Singh RandhawaMilind Y Desai

❮ Previous
Next ❯

Citations

Feb 10, 2018·Biomarkers in Medicine·Felipe FalcãoDário C Sobral Filho
Jul 10, 2018·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Nicola TarantinoNatale Daniele Brunetti
Apr 24, 2019·Physics in Medicine and Biology·Peng PengSimon R Cherry
Apr 21, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Thomas StiermaierIngo Eitel
Apr 12, 2020·Trends in Cardiovascular Medicine·Andra Maria Ciutac, Dana Dawson
Aug 18, 2021·Scientific Reports·Francesco SantoroNatale Daniele Brunetti
Aug 20, 2016·Future Cardiology·Natale Daniele BrunettiMatteo Di Biase

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.