Carbohydrate-Based Micro/Nanocapsules With Controlled External Surface for Medical Applications

Frontiers in Chemistry
Roman BielskiJohn F L Newport

Abstract

Micro/nanocapsules would have many more applications if we were able to controllably populate their surface with various chemical moieties. The present review introduces a novel variant of interfacial polymerization (IP) as a very robust method of manufacturing reservoir micro/nanocapsules equipped with several different functionalities on the capsules' surface. We call the method-IPCESCO (Interfacial Polymerization for Capsules' External Surface Control). As always in IP, the capsules' forming reaction is between monomers dissolved in opposite phases (oil or water) and takes place at the interface. Each monomer carries two or more functionalities reacting with functional groups of the monomer dissolved in the other phase. IPCESCO requires that one or both monomers are additionally equipped with (protected) functional groups interfering neither with the payload nor with the polymer formation. These additional groups end up everywhere in the polymeric shell but most importantly they are present on the external surface of capsules. These "handles" allow for the introduction of various moieties onto the capsules' surface. Since carbohydrate chemists developed a plurality of protecting and deprotecting methods for various functiona...Continue Reading

References

Nov 18, 2005·Bioorganic & Medicinal Chemistry Letters·Teruki TakahashiAkito Tanaka
Aug 29, 2009·Angewandte Chemie·Ellen M Sletten, Carolyn R Bertozzi
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hideaki ShibataShoji Takeuchi
Jul 28, 2011·Chemical Society Reviews·Alessandro Dondoni, Alberto Marra
Dec 16, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Lena J DaumannLawrence R Gahan
Aug 28, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jiani ZhengXiaojun Ma
Nov 17, 2012·Chemical Reviews·Roman Bielski, Zbigniew Witczak
Feb 12, 2013·Chemical Reviews·Robert-Jan van PuttenJohannes G de Vries
Feb 19, 2013·Chemistry : a European Journal·David C KennedyPeter H Seeberger
Jun 19, 2013·Advances in Cancer Research·Angela A Alexander-BryantXuejun Wen
Nov 13, 2013·Chemical Communications : Chem Comm·Timothy R PearceEfrosini Kokkoli
Nov 26, 2013·Chemistry & Biology·Jason E Hudak, Carolyn R Bertozzi
Feb 5, 2014·Journal of Nanobiotechnology·Li ShangGerd Ulrich Nienhaus
May 30, 2014·International Journal of Nanomedicine·Nuri Oh, Ji-Ho Park
Sep 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guanghui Ma
Sep 30, 2014·Journal of Microencapsulation·Carole PerignonDenis Poncelet
Dec 29, 2015·Chemical Reviews·Keti PiradashviliKatharina Landfester
Jun 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abhijit A DateLaura M Ensign
Apr 27, 2017·International Journal of Nanomedicine·Hossein JahangirianYadollah Abdollahi

❮ Previous
Next ❯

Methods Mentioned

BETA
membrane filtration

Software Mentioned

IPCESCO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.