PMID: 6968070Jun 1, 1980Paper

Carbohydrate-binding component of amphibian embryo cell surfaces: restriction to surface regions capable of cell adhesion

Proceedings of the National Academy of Sciences of the United States of America
M M Roberson, P B Armstrong

Abstract

Superficial cells from early amphibian embryos display regional specializations of their cell surfaces. That portion of the plasma membrane facing the perivitelline space (apical surface) is nonadhesive, whereas, in the same cell, the lateral and basal portions of the plasma membrane will adhere to other cells. These adhesive differences are maintained on single cells that have been dissociated from the intact embryo. Extracts of cleavage-stage Rana pipiens embryos are capable of agglutinating formalinized sheep erythrocytes. The hemagglutination activity can be blocked by a yeast mannan and a family of glycoproteins containing high levels of mannose, indicating the presence of a lectin with oligomannosyl specificity. The cell surface location of this carbohydrate-binding component can be demonstrated by the ability of the formalinized sheep erythrocytes to form rosettes with living dissociated embryonic superficial cells. Rosette formation is blocked by the same inhibitors that are effective in blocking the activity of the crude extracts. The formalinized sheep erythrocytes form rosettes only to those cell surface regions of the superficial cells that are capable of adhering to other amphibian embryo cells. Receptors for conca...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P D StahlP H Schlesinger
Aug 1, 1979·Experimental Cell Research·M M Roberson, P B Armstrong
Nov 21, 1977·Biochemical and Biophysical Research Communications·T K GartnerD R Phillips
Mar 20, 1978·Biochimica Et Biophysica Acta·F B DazzoW J Brill
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·K M YamadaI Pastan

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Citations

Apr 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H A Müller, P Hausen
Aug 1, 1982·In Vitro·S G PhillipsD M Phillips
Jul 1, 1984·Developmental Biology·P A TetterooS W de Laat
Oct 1, 1985·Developmental Biology·J J DeGeorgeS Carbonetto
Jun 1, 1986·The Journal of Cell Biology·T J Byers, P B Armstrong
Aug 1, 1983·The Journal of Cell Biology·L Pollack, P H Atkinson
Dec 1, 1983·The Journal of Cell Biology·D KlineR Nuccitelli
Dec 1, 1983·The Journal of Cell Biology·M M Roberson, S H Barondes
Jan 1, 1986·Progress in Histochemistry and Cytochemistry·E J Sanders
Sep 1, 1981·Developmental Biology·L M Wiley, M A Eglitis
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·P B Armstrong
Apr 15, 1983·Experimental Cell Research·J T Sawyer, R A Akeson

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