PMID: 9660318Jul 11, 1998Paper

Carbohydrate-deficient transferrin and conventional alcohol markers as indicators for brief intervention among heavy drinkers in primary health care

Alcoholism, Clinical and Experimental Research
P SillanaukeeK Seppä

Abstract

Brief intervention is a promising treatment for heavy drinking. The present study examined the diagnostic value of carbohydrate-deficient transferrin (CDT), mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) in detecting early-phase heavy drinkers for brief intervention treatment in primary health care. Laboratory data were collected from consecutive 20- to 60-year-old, early-phase heavy drinkers (329 males and 136 females), who were willing to undergo brief intervention treatment in five primary health care outpatient clinics. An elevated value of at least 1 of the 5 markers studied was found in 75% of the male and in 76% of the female heavy drinkers. The sensitivities of CDT, MCV, AST, ALT and GGT values were low; in men, respectively, 39%, 28%, 12%, 28%, and 33%, and in women 29%, 40%, 20%, 29%, and 34%. However, marker combinations, including CDT, reached a good level of sensitivity; the best triple combination (CDT or MCV or GGT) was positive in 69% of the men and 70% of the women. According to logistic regression, the age of the patient had an increasing effect on MCV, ALT and GGT. High body mass index increased all transaminases and decreas...Continue Reading

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Citations

Jun 15, 2004·Drug and Alcohol Dependence·Raymund SchwanPierre-Michel Llorca
Jan 30, 2003·Clinical Biochemistry·Janine Denis Cook
May 20, 2005·The New England Journal of Medicine·Raymund Schwan, John P Allen
Jun 19, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Klaus Golka, Andreas Wiese
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