Abstract
To test the reliability and validity of a new alcohol biomarker. Cross-sectional with matched control. Alcohol use, symptoms of alcohol dependence, health status, current medications, carbohydrate-deficient transferrin (CDT) levels, and gamma-glutamyl transferase levels were assessed. Validity of the %CDT test was estimated using a drinking cutoff of 90 or more drinks in the previous 30 days. Sample (n = 799) included 89 patients with type 2 diabetes, 299 patients with hypertension, 209 patients with hypertension and type 2 diabetes, and 202 matched control subjects with neither diabetes nor hypertension. Three hundred ninety-six women and 403 men ages 30 to 60 participated in the study. Six percent (45 of 799) reported drinking more than 14 drinks per week, 2% (n = 17) met criteria for alcohol abuse, and 3% (n = 23) met DSM-IV criteria for dependence. The overall sensitivity of the %CDT test was 61% with a specificity of 85%. A receiver operating characteristic curve was used to determine that the best fit was for persons who reported >90 drinks per month and a CDT level >2.5% with an area under the curve of 0.83. Test-retest reliability (R) was 0.94. %CDT levels are useful in detecting and/or confirming high-risk drinking in ...Continue Reading
Citations
Jun 10, 2010·Acta Diabetologica·Patricia A EnglerRobert J Smith
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raymond F AntonDidier Meulien
Aug 16, 2008·The New England Journal of Medicine·Raymond F Anton
May 9, 2014·PloS One·Vikram PuvennaDamir Janigro
Aug 10, 2005·The Journal of Clinical Hypertension·Peter M MillerShaun A Nguyen
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Peter M MillerKathryn Sullivan Dillie
Sep 4, 2004·Addictive Behaviors·Peter M Miller, Raymond F Anton
Dec 25, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jonas P Bergström, Anders Helander
Jul 17, 2007·Orvosi hetilap·György SzabóJános Fehér
Mar 21, 2012·Orvosi hetilap·György SzabóJános Fehér
Feb 23, 2008·Orvosi hetilap·György SzabóJános Fehér
Oct 28, 2008·Orvosi hetilap·György SzabóJános Fehér
Mar 23, 2010·Substance Abuse : Research and Treatment·Susan E RamseyPeter Friedmann
Mar 1, 2007·Journal of Addiction Medicine·Jeffrey S CluverRaymond F Anton
Aug 17, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·François SchellenbergMichel Reynaud
Dec 13, 2005·Alcoholism, Clinical and Experimental Research·Kathryn Sullivan DillieMichael F Fleming
Sep 22, 2019·Acta Anaesthesiologica Scandinavica·Eliisa UljasJohanna Hästbacka
Jun 13, 2020·Diabetes Care·Kevin M PantaloneMichael W Kattan
Jan 1, 2009·Substance Abuse : Research and Treatment·Susan E Ramsey, Patricia A Engler