PMID: 3747492Jun 1, 1986Paper

Carbohydrate diet-induced calcium bilirubinate sludge and pigment gallstones in the prairie dog

The Journal of Surgical Research
R L ConterL DenBesten

Abstract

Epidemiologic studies suggest that consumption of diets rich in carbohydrates may, in part, be responsible for the increasing incidence of pigment gallstone disease. The mechanism by which these dietary components lead to pigment stone formation remains obscure. Furthermore, investigative efforts in this area have been hampered by the lack of a suitable animal model. The present study was undertaken to study the role of complex carbohydrates in pigment gallstone formation in the prairie dog. Two groups of eight animals each were maintained on either a control, nonlithogenic chow, or a high carbohydrate (35% sucrose, 32% rich starch) diet for 2 months. Neither crystals nor gallstones were observed in any of the control animals. All of the carbohydrate fed animals (P less than 0.005 vs control) had calcium bilirubinate crystals and sludge, while microscopic, black stones were present in six of these eight animals (P less than 0.05 vs control). Although hepatic bile bilirubin was unchanged in the carbohydrate-fed group, these animals had a significant increase in hepatic bile calcium (P less than 0.005) and phospholipids (P less than 0.005) when compared to controls. Carbohydrate-fed animals also had a significant increase in gall...Continue Reading

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Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A F AttiliD Festi
Feb 1, 1996·Digestive Diseases and Sciences·J MatsumuraR V Rege
Apr 1, 1989·The Journal of Surgical Research·T H MagnusonH A Pitt
Jun 1, 1988·Annals of Surgery·W H SchwesingerR Johnson
Jun 1, 1990·The Journal of Surgical Research·D E ScheeresK D Lillemoe
May 1, 1991·The Journal of Surgical Research·H S KaufmanK D Lillemoe
May 1, 1991·The Journal of Surgical Research·T H MagnusonH A Pitt
Feb 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F E Murray, C J Hawkey
Jan 1, 1988·American Journal of Surgery·S D StrichartzJ J Roslyn
Jan 1, 1989·American Journal of Surgery·S D StrichartzJ J Roslyn
May 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·G BroughtonG Anthone
Aug 20, 2003·European Journal of Clinical Investigation·L Vítek, M C Carey

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