Carbohydrate engineered cells for regenerative medicine.

Advanced Drug Delivery Reviews
Jian Du, Kevin J Yarema

Abstract

Carbohydrates are integral components of the stem cell niche on several levels; proteoglycans are a major constituent of the extracellular matrix (ECM) surrounding a cell, glycosoaminoglycans (GAGs) help link cells to the ECM and the neighboring cells, and small but informationally-rich oligosaccharides provide a "sugar code" that identifies each cell and provides it with unique functions. This article samples roles that glycans play in development and then describes how metabolic glycoengineering - a technique where monosaccharide analogs are introduced into the metabolic pathways of a cell and are biosynthetically incorporated into the glycocalyx - is overcoming many of the long-standing barriers to manipulating carbohydrates in living cells and tissues and is becoming an intriguing new tool for tissue engineering and regenerative medicine.

Citations

Dec 30, 2014·Advanced Drug Delivery Reviews·Diana GasparDimitrios Zeugolis
Jun 14, 2014·Chemical Biology & Drug Design·Long Chen, Jun F Liang
Apr 7, 2012·Carbohydrate Research·Marcus V C CardosoEdvaldo Sabadini
Apr 11, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Long Chen, Jun F Liang
Sep 20, 2011·Advanced Drug Delivery Reviews·Subinoy RanaVincent M Rotello
May 4, 2012·Journal of Tissue Engineering and Regenerative Medicine·A SatyamD I Zeugolis
Dec 27, 2012·IEEE Reviews in Biomedical Engineering·Pinar ZorlutunaAli Khademhosseini
Jun 23, 2015·Chemistry : a European Journal·Alberto Fernández-TejadaJesús Jiménez-Barbero
Mar 22, 2015·Glycobiology·Cristina Y ZamoraKrishna Kumar
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