Carbohydrate-independent recognition of collagens by the macrophage mannose receptor.

European Journal of Immunology
Luisa Martinez-PomaresSiamon Gordon

Abstract

Mannose receptor (MR) is the best characterised member of a family of four endocytic molecules that share a common domain structure; a cysteine-rich (CR) domain, a fibronectin-type II (FNII) domain and tandemly arranged C-type lectin-like domains (CTLD, eight in the case of MR). Two distinct lectin activities have been described for MR. The CR domain recognises sulphated carbohydrates while the CTLD mediate binding to mannose, fucose or N-acetylglucosamine. FNII domains are known to be important for collagen binding and this has been studied in the context of two members of the MR family, Endo180 and the phospholipase A2 receptor. Here, we have investigated whether the broad and effective lectin activity mediated by the CR domain and CTLD of MR is favoured to the detriment of FNII-mediated interaction(s). We show that MR is able to bind and internalise collagen in a carbohydrate-independent manner and that MR deficient macrophages have a marked defect in collagen IV and gelatin internalisation. These data have major implications at the molecular level as there are now three distinct ligand-binding sites described for MR. Furthermore our findings extend the range of endogenous ligands recognised by MR, a molecule firmly placed a...Continue Reading

References

Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J FieteJ U Baenziger
Jul 7, 1998·The Journal of Experimental Medicine·F S SutterwalaD M Mosser
Jan 15, 2000·The Journal of Biological Chemistry·N BehrendtK Danø
Mar 9, 2002·Science·Sena J LeeMichel C Nussenzweig
Aug 28, 2002·The Journal of Biological Chemistry·Susanne ZamzeSimon Y C Wong
Sep 12, 2002·Biochimica Et Biophysica Acta·Lucy East, Clare M Isacke
Oct 26, 2002·The Journal of Biological Chemistry·Lucy EastClare M Isacke
Dec 24, 2002·Infection and Immunity·Sena J LeeMichel C Nussenzweig
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Apr 26, 2003·Journal of Leukocyte Biology·Luisa Martinez-PomaresSimon Y C Wong
Jul 5, 2003·Current Biology : CB·Paul MartinScott R McKercher
Jan 20, 2004·Experimental Cell Research·Lars KjøllerNiels Behrendt
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Philip R TaylorLuisa Martinez-Pomares
Mar 23, 2004·Annual Review of Immunology·Sidney PestkaPaul B Fisher
Jan 19, 2005·Clinical and Experimental Immunology·G D ChazenbalkS M McLachlan
Jan 26, 2005·Trends in Immunology·Philip R TaylorLuisa Martinez-Pomares
Jun 29, 2005·The Journal of Biological Chemistry·Yunpeng SuLuisa Martinez-Pomares

❮ Previous
Next ❯

Citations

Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sven BurgdorfChristian Kurts
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vania CoelhoFreda K Stevenson
Jan 6, 2011·The Journal of Biological Chemistry·Umut GaziLuisa Martinez-Pomares
Jul 20, 2011·The Journal of Biological Chemistry·Henrik J JürgensenNiels Behrendt
Sep 11, 2013·The Journal of Cell Biology·Daniel H MadsenThomas H Bugge
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Daryl M OkamuraAllison A Eddy
Apr 22, 2010·The Journal of Clinical Investigation·Konstantia-Maria ChaveleAlan D Salama
Apr 25, 2008·Blood·Fumiko Marttila-IchiharaSirpa Jalkanen
Feb 13, 2008·PLoS Pathogens·Joanna L MillerSiamon Gordon
Nov 24, 2011·International Journal of Biological Sciences·Vanina V GarridoFabio M Cerbán
Jul 26, 2006·The Journal of Cell Biology·Katie M Jansen, Grace K Pavlath
Jun 6, 2008·Expert Opinion on Drug Delivery·Juan M IracheSocorro Espuelas
Sep 1, 2015·International Journal of Oncology·Maria C MelanderNiels Behrendt
Oct 4, 2011·The Journal of Allergy and Clinical Immunology·Eszter HerczenikJan Voorberg
Dec 5, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Birgit Leitinger, Erhard Hohenester
Nov 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kjetil ElvevoldKaren Kristine Sørensen
Feb 2, 2012·The Journal of Pathology·Daniel H MadsenNiels Behrendt
Dec 4, 2008·Journal of Biomedical Materials Research. Part a·Amy S ChungWeiyuan John Kao
Oct 10, 2013·Journal of Neuroscience Research·Litia A CarvalhoLeny A Cavalcante
Apr 14, 2016·Fish & Shellfish Immunology·Xiangli DongChangwen Wu
Oct 30, 2012·Experimental and Molecular Pathology·Yinglin LiuDebra L Laskin
Jan 24, 2009·Immunobiology·Umut Gazi, Luisa Martinez-Pomares
Mar 6, 2009·Immunobiology·Ann M Kerrigan, Gordon D Brown
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Verena SchuetteSven Burgdorf
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Wen-Juan LiMing-Yong Xie
Apr 4, 2012·Current Protocols in Immunology·Luisa Martinez-Pomares
Dec 15, 2017·Frontiers in Immunology·Irma van Die, Richard D Cummings
Jun 29, 2007·Journal of Leukocyte Biology·Justin SturgeClare M Isacke
May 24, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ivana MalovicPeter A G McCourt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.