PMID: 8944667Nov 1, 1996Paper

Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans

The American Journal of Physiology
A L GreenP L Greenhaff

Abstract

This study investigated the effect of carbohydrate (CHO) ingestion on skeletal muscle creatine (Cr) accumulation during Cr supplementation in humans. Muscle biopsy, urine, and plasma samples were obtained from 24 males before and after ingesting 5 g Cr in solution (group A) or 5 g Cr followed, 30 min later, by 93 g simple CHO in solution (group B) four times each day for 5 days. Supplementation resulted in an increase in muscle phosphocreatine (PCr), Cr, and total creatine (TCr; sum of PCr and Cr) concentration in groups A and B, but the increase in TCr in group B was 60% greater than in group A (P < 0.01). There was also a corresponding decrease in urinary Cr excretion in group B (P < 0.001). Creatine supplementation had no effect on serum insulin concentration, but Cr and CHO ingestion dramatically elevated insulin concentration (P < 0.001). These findings demonstrate that CHO ingestion substantially augments muscle Cr accumulation during Cr feeding in humans, which appears to be insulin mediated.

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Citations

Mar 3, 2007·The Journal of Physiology·Francis B StephensPaul L Greenhaff
Jul 8, 2010·Amino Acids·Nelo Eidy ZanchiAntonio Herbert Lancha
Aug 4, 2001·Journal of Applied Physiology·P Greenhaff
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Aug 24, 2000·Journal of Applied Physiology·G R SteengeP L Greenhaff
Feb 15, 2001·American Journal of Physiology. Cell Physiology·R MurphyR Snow
Sep 12, 2019·Frontiers in Nutrition·Pedro PerimBryan Saunders
Jul 30, 2004·American Journal of Physiology. Cell Physiology·Robyn M MurphyGraham D Lamb
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Bernd WalzelTheo Wallimann
Jan 7, 2003·Journal of Applied Physiology·Jeffrey J BraultRonald L Terjung
Feb 2, 2017·American Journal of Physiology. Endocrinology and Metabolism·Colleen S DeanePhilip J Atherton
Jun 3, 2017·Journal of Applied Physiology·Marina Yazigi SolisBruno Gualano
Sep 19, 2019·Sports Medicine·Jeffrey A Rothschild, David J Bishop
Mar 23, 2011·Amino Acids·Ralf JägerRichard B Kreider
Feb 13, 2021·Nutrients·Richard B Kreider, Jeffery R Stout
Jan 23, 2021·Journal of the International Society of Sports Nutrition·Amir SarshinAlireza Naderi
Mar 31, 2021·Journal of the American College of Nutrition·Astrid PfeifferAdriano Eduardo Lima-Silva
Jun 15, 2021·BMC Sports Science, Medicine and Rehabilitation·Guillermo EscalanteBrad J Schoenfeld
Jul 9, 2021·Current Sports Medicine Reports·Matthew HallKristofer Tupper
Aug 28, 2021·Nutrients·Felipe RibeiroBryan Saunders
Nov 11, 2021·Adapted Physical Activity Quarterly : APAQ·Andreia BauermannAnselmo A Costa E Silva
Mar 3, 2006·Pediatrics·Ryan Calfee, Paul Fadale

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