Carbohydrate metabolism and endocrine function in the pancreas remnant after major pancreatic resection

American Journal of Surgery
R MizumotoI Tomikawa

Abstract

Changes in glucose tolerance, in secretion of pancreatic hormones and in the islets of the pancreas were investigated after major resection of the pancreas in dogs to elucidate the pathophysiologic features of carbohydrate metabolism and the difference in the amount of insulin required in diabetes after total and partial pancreatectomy. In diabetes after 90 percent or more pancreatectomy, both insulin secretion and the function of the anti-insulin system decreased, associated with degeneration of the islet B, A, and D cells. The required insulin amount was similar to that needed after total pancreatectomy. Diabetes developed more than 6 weeks after 70 to 90 percent pancreatectomy, and insulin secretion decreased but the function of the anti-insulin system was accentuated with an increase in plasma glucagon levels, associated with degeneration in B cells but not in A and D cells. The amount of insulin required was 3 to 4 times greater than that needed after total pancreatectomy.

References

Jul 16, 1970·The New England Journal of Medicine·W A MüllerR H Unger
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Citations

Feb 6, 2016·American Journal of Surgery·Takahiro AkahoriYoshiyuki Nakajima
Jan 1, 1989·American Journal of Surgery·J D BarrJ B Hanks
Sep 20, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ricardo V CohenDavid E Cummings
Jan 17, 2013·Clinical and Molecular Hepatology·Eun Hui SimKyu Won Chung
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M LöhrG Klöppel
Dec 1, 1991·Gastroenterologia Japonica·Y KawaradaR Mizumoto
Mar 29, 1990·The New England Journal of Medicine·D M KendallR P Robertson
Oct 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·R MizumotoY Kawarada

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