Carbohydrate recognition by Clostridium difficile toxin A

Nature Structural & Molecular Biology
Antonio GrecoKenneth K-S Ng

Abstract

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

References

Jan 1, 1991·Infection and Immunity·K D Tucker, T D Wilkins
Jan 1, 1996·Annual Review of Biochemistry·W I Weis, K Drickamer
Sep 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·A K Roberts, C C Shone
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·C B KurtzJ D Klinger
Jun 4, 2002·Glycobiology·Francisco CorzanaAnne Imberty
Jul 9, 2004·Biophysical Journal·William BraunlinCaroline B Kurtz
Jan 28, 2005·Journal of Medical Microbiology·Maja RupnikChristoph von Eichel-Streiber
Apr 16, 2005·Clinical Microbiology Reviews·Daniel E Voth, Jimmy D Ballard
Dec 3, 2005·The New England Journal of Medicine·John G Bartlett, Trish M Perl
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason G S HoKenneth K-S Ng

❮ Previous
Next ❯

Citations

May 9, 2008·Current Infectious Disease Reports·David A Bobak
Jun 26, 2009·The Journal of Biological Chemistry·Rory N PruittD Borden Lacy
May 26, 2011·Glycobiology·Amr El-HawietJohn S Klassen
May 30, 2013·Infection and Immunity·Rosanna LeuzziMaria Scarselli
Oct 15, 2009·Future Microbiology·Michel R Popoff, Philippe Bouvet
Jul 1, 2010·Toxins·Xingmin SunHanping Feng
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rory N PruittD Borden Lacy
Apr 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Björn SchorchKlaus Aktories
Jul 14, 2009·Expert Opinion on Biological Therapy·Elizabeth YurievPaul A Ramsland
Jan 30, 2008·Journal of Pharmaceutical Sciences·Maya S SalnikovaC Russell Middaugh
Jun 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michelle E LaFranceD Borden Lacy
Oct 2, 2015·Journal of the American Society for Mass Spectrometry·Jingjing ZhangJohn S Klassen
Aug 4, 2009·Biochimica Et Biophysica Acta·Yury Belyi, Klaus Aktories
Apr 9, 2008·Trends in Microbiology·Thomas Jank, Klaus Aktories
Mar 8, 2008·Journal of Molecular Biology·Mathias O P ZieglerGeorg E Schulz
Oct 8, 2015·Cellular Microbiology·Thomas JankKlaus Aktories
Feb 6, 2010·Medicinal Research Reviews·Ashish A KulkarniSuri S Iyer
Feb 11, 2015·Human Vaccines & Immunotherapeutics·Song ZhaoXingmin Sun
May 16, 2008·Journal of Medical Microbiology·Torsten GiesemannKlaus Aktories
Apr 6, 2013·Journal of Medical Microbiology·Ralf GerhardAlexandra Olling
May 28, 2011·The Biochemical Journal·Abigail H DaviesK Ravi Acharya
Jan 15, 2010·Journal of Molecular Biology·David Albesa-JovéKatherine A Brown
Feb 13, 2010·MAbs·Stephen J DemarestGeneviève Hansen
Feb 22, 2008·The International Journal of Biochemistry & Cell Biology·Harald GenthIngo Just
Nov 20, 2016·FEBS Letters·Gregory S Lambert, Michael R Baldwin
May 27, 2017·Critical Reviews in Biochemistry and Molecular Biology·Kathleen E OrrellRoman A Melnyk
Nov 18, 2014·Inflammatory Bowel Diseases·Darren N Seril, Bo Shen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.