PMID: 8468354Apr 1, 1993Paper

Carbohydrate recognition in the peripheral nervous system: a calcium-dependent membrane binding site for HNK-1 reactive glycolipids potentially involved in Schwann cell adhesion

The Journal of Cell Biology
L K Needham, R L Schnaar

Abstract

The carbohydrate determinants recognized by the HNK-1 antibody are potential cell-cell recognition ligands in the peripheral nervous system (PNS). The HNK-1 reactive sulfoglucuronylneolacto (SGNL) glycolipids specifically support Schwann cell adhesion, suggesting the presence of a cell surface receptor specific for SGNL-oligosaccharides. We directly probed PNS membranes for receptors complementary to SGNL determinants using a synthetic radioligand consisting of radioiodinated serum albumin derivatized with multiple SGNL-oligosaccharides. A high-affinity, saturable, calcium-dependent binding site for this ligand was found in PNS myelin membranes. Binding activity was carbohydrate-specific (most potently inhibited by SGNL-lipids compared to other glycolipids) and PNS-specific (absent from comparable central nervous system membranes). The SGNL-specific binding activity on PNS membranes reported here may be involved in peripheral myelination or myelin stabilization.

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Citations

Feb 1, 1997·Journal of Molecular Neuroscience : MN·R H Quarles
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
Apr 27, 2005·Journal of the Neurological Sciences·Moeko NoguchiMasahito Yamada
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·L J YangR L Schnaar
Aug 14, 1997·Biochimica Et Biophysica Acta·J A Mahoney, R L Schnaar
Oct 28, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sabrina MatàSandro Sorbi
Apr 10, 1999·The Journal of Biological Chemistry·R MiuraY Yamaguchi
Sep 20, 1996·The Journal of Biological Chemistry·H VosholM Schachner
Jul 9, 1999·Muscle & Nerve·R H Quarles, M D Weiss
Jun 1, 1996·Neuroscience Research·C Ide

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