Carbohydrate requirement and insulin concentration during moderate exercise in type 1 diabetic patients

Metabolism: Clinical and Experimental
Maria Pia FrancescatoLuigi Cattin

Abstract

The lack in control of insulin release combined with an inadequate carbohydrate (CHO) ingestion accounts for the occurrence of frequent metabolic unbalances during exercise in type 1 diabetic patients. The aim of the study was to quantify, in these patients, the CHO requirement to prevent hypoglycemia during moderate exercise performed at different time intervals after morning subcutaneous insulin injection. Twelve type 1 diabetic patients and 12 well-matched healthy subjects cycled 4 times for 1 hour at a constant workload. The rate of glucose oxidation was calculated continuously by indirect calorimetry throughout the exercise, while blood parameters were assessed periodically and orally given CHO were checked. CHO needed by the patients to prevent hypoglycemia decreased as the time elapsed from insulin administration increased, amounting to 0.63 +/- 0.30, 0.44 +/- 0.32, 0.28 +/- 0.24, and 0.14 +/- 0.18 g/kg after 1, 2.5, 4, and 5.5 hours, respectively. Total glucose requirement during moderate exercise (sum of alimentary and extracellular source) was correlated (r = 0.739, P <.001) to plasma insulin concentration, but not with fitness level. Time elapsed from last insulin dose is not a factor influencing the risk of hypoglyc...Continue Reading

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Citations

Jan 5, 2011·Diabetes, Obesity & Metabolism·I W GallenA Lumb
May 18, 2010·Medicine and Science in Sports and Exercise·Maria Pia FrancescatoClaudio Noacco
Nov 23, 2012·Diabetes Care·Jane E YardleyRonald J Sigal
Feb 23, 2011·Expert Review of Endocrinology & Metabolism·Lisa M YounkStephen N Davis
Jul 3, 2013·Metabolism: Clinical and Experimental·Katharine E HallC W James Melling
Feb 5, 2013·Metabolism: Clinical and Experimental·Mario GeatMaria Pia Francescato
Jul 24, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·A S BrazeauR Rabasa-Lhoret
Mar 11, 2015·Pediatric Diabetes·Jacklyn A PivovarovMichael C Riddell
Jan 9, 2019·Diabetes Technology & Therapeutics·Marie-Anne BurckhardtElizabeth A Davis
Feb 16, 2019·Journal of Diabetes Science and Technology·Maria Pia FrancescatoAgostino Accardo
Jun 20, 2013·The Journal of Clinical Endocrinology and Metabolism·Raymond J DaveyTimothy W Jones
Sep 30, 2016·International Journal of Endocrinology and Metabolism·William B Horton, Jose S Subauste
Jul 2, 2019·Frontiers in Endocrinology·Tarini ChettyElizabeth Ann Davis
Dec 15, 2019·Nutrients·Sam ScottChristoph Stettler
Aug 4, 2020·Journal of Diabetes Science and Technology·Miloš AjčevićMaria Pia Francescato
Oct 16, 2019·Frontiers in Physiology·Christophe KosinskiFrancesca Amati
Oct 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Vinutha B ShettyElizabeth A Davis

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