Carbohydrates of the surface of the normal human spermatozoon

American Journal of Reproductive Immunology and Microbiology : AJRIM
M N MazziniA S Cerezo

Abstract

Autoproteolysis of human spermatozoa produces oligopeptides with oligosaccharide chains of the N-glycosidic-linked type that are released from the "surface exposed" parts of glycoproteins. The products eluted in the previous washing of the spermatozoa have the same composition and solubility characteristics as the oligopeptides from the digestion. This suggests that autoproteolysis is a constant process that normally occurs on the spermatozoa membrane. The cytochemical characterization and localization of the N-glycosidic-linked oligosaccharide receptors on the human spermatozoa membrane after digestion, in the presence or absence of seminal plasma, indicates that only part of the oligosaccharides are cleaved. Their distribution on the different zones of the spermatozoon changed as the probability of detecting these receptors in the intermediate segment increased after proteolysis; this indicates that in this zone the receptors are cryptic ones that become exposed by the action of the proteolytic enzymes. In the presence of seminal plasma most receptors on the acrosome are eliminated.

References

Oct 1, 1977·Analytical Biochemistry·V F Kalb, R W Bernlohr
Jan 1, 1975·Fertility and Sterility·J M Scacciati, R E Mancini
May 1, 1970·Virology·P Häyry, V Defendi
Jun 1, 1972·Journal of Reproduction and Fertility·L Benítez-Bribiesca, S Velázquez-Meza
Mar 1, 1969·Journal of Reproduction and Fertility·P J QuinnK W Cleland
Sep 1, 1983·American Journal of Reproductive Immunology : AJRI·H TortorellaA S Cerezo
Oct 1, 1982·American Journal of Reproductive Immunology : AJRI·J M Scacciati de CerezoA S Cerezo
Jan 1, 1980·Advances in Carbohydrate Chemistry and Biochemistry·J Montreuil
Oct 15, 1980·Carbohydrate Research· Nasir-ud-DinM Shalev

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Citations

Jul 1, 1994·Journal of Assisted Reproduction and Genetics·P F LevayF R Fourie
May 1, 1989·American Journal of Reproductive Immunology : AJRI·J M CerezoA S Cerezo
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·W H KuttehB R Carr
Mar 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H TortorellaA Brandelli

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