Carbohydrates: Potential Sweet Tools Against Cancer

Current Medicinal Chemistry
Antonio FranconettiJosé G Fernandez-Bolanos

Abstract

Cancer, one of the most devastating degenerative diseases nowadays, is one of the main targets in Medicinal Chemistry and Pharmaceutical industry. Due to the significant increase in the incidence of cancer within world population, together with the complexity of such disease, featured with a multifactorial nature, access to new drugs targeting different biological targets connected to cancer is highly necessary. Among the vast arsenal of compounds exhibiting antitumor activities, this review will cover the use of carbohydrate derivatives as privileged scaffolds. Their hydrophilic nature, together with their capacity of establishing selective interactions with biological receptors located on cell surface, involved in cell-to-cell communication processes, has allowed the development of an ample number of new templates useful in cancer treatment. Their intrinsic water solubility has allowed their use as of pro-drug carriers for accessing more efficiently the pharmaceutical targets. The preparation of glycoconjugates in which the carbohydrate is tethered to a pharmacophore has also allowed a better permeation of the drug through cellular membranes, in which selective interactions with the carbohydrate motifs are involved. In this c...Continue Reading

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Citations

Apr 3, 2020·Current Medicinal Chemistry·Dean Marković, Krešimir Pavelić
Jul 16, 2021·Carbohydrate Research·Rituparna Das, Balaram Mukhopadhyay

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