Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis

International Journal of Biological Macromolecules
Priyanka TripathiJay Ram Patel

Abstract

The present investigation reports the evaluation of potential use of Carbomer gel bearing methotrexate loaded nanostructured lipid carriers for topical application of methotrexate for possible therapy of psoriasis in comparison to solid lipid nanoparticles. These were evaluated for various parameters such as particle size, surface charge, entrapment efficiency, shape and surface morphology, thermal analysis, in-vitro drug release through skin (Franz diffusion cell) and drug deposition study, fluorescence microscopy, particle-skin interaction study, skin-irritation testing and storage stability. The formulation (NLC5) showed the best entrapment efficiency (62.72 ± 0.94%) while SLN showed only 26.84 ± 0.64% with particle size of 221 ± 14nm and 212 ± 11nm, respectively. Skin permeation study of MTX loaded SLN and NLC5 hydrogels showed prolonged drug release up to 24 h. The skin drug deposition study showed the greatest deposition of drug enriched NLC5 hydrogel (28.8%) when compared to plain drug enriched hydrogel (11.4%) and drug enriched SLN hydrogel (18.6%). Fluorescence microscopy suggested the localization effect of these lipid based systems to deeper skin region. The primary skin irritation studies indicated that MTX loaded S...Continue Reading

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Citations

Nov 23, 2019·Current Drug Delivery·Arya Kadukkattil RamanunnyAnkit Awasthi
Jun 25, 2019·Current Medicinal Chemistry·Bruno Fonseca-SantosMarlus Chorilli
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sevgi Güngör, Emine Kahraman
Jun 3, 2021·International Journal of Molecular Sciences·Agnieszka Kulawik-Pióro, Małgorzata Miastkowska
Jul 25, 2021·International Journal of Molecular Sciences·Joanna Skopinska-WisniewskaJustyna Kozlowska
Jun 5, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Arya K RamanunnyRajesh Kumar

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