Carbon-11 and iodine-123 labelled iomazenil: a direct PET-SPET compari son

European Journal of Nuclear Medicine
G WesteraA P Schubiger

Abstract

The benzodiazepine receptor ligand iomazenil was labelled with carbon-11 to allow a direct positron emission tomography/single-photon emission tomography (PET/SPET) comparison with the well-known iodine-123 labelled compound. Imaging showed the same regional distribution for both modalities. Blood sample activity was corrected for metabolites by extraction with chloroform and high-performance liquid chromatographic analysis. Metabolism is very fast: 5min after application more than 85% of the plasma activity is present as hydrophilic metabolites. Kinetic methods were used to obtain regional estimates of transport rate constants and receptor concentrations. A three-compartment model was employed which gave transport rate constants for brain uptake (K1) and the distribution volume for the specifically receptor bound compartment (DVS). K1 varied from 0.32 to 0.50ml/min per gram for the cortical regions, cerebellum, thalamus and striatum for PET and SPET. Mean DVS-PET and DVS-SPET values were, respectively, 23+/-5 and 31+/-5ml/g for the occipital cortex, 11+/-3 and 15+/-2ml/g for the cerebellum, 7+/-2 and 11+/-3ml/g for the thalamus, 5+/-3 and 10+/-3ml/g for the striatum, and 3+/-2 and 3+/-1ml/g for the pons. These values correlate...Continue Reading

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Citations

May 1, 1996·European Journal of Nuclear Medicine·C Burger, A Buck
Aug 31, 2013·Current Neurology and Neuroscience Reports·Henning Boecker
May 22, 1998·Clinical Nuclear Medicine·J HashimotoY Fukuuchi
Apr 12, 2005·Nuclear Medicine and Biology·Young Soo ChangMyung Chul Lee
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