PMID: 20645915Jul 22, 2010Paper

Carbon-11 labeled tracers for in vivo imaging P-glycoprotein function: kinetics, advantages and disadvantages

Current Topics in Medicinal Chemistry
Gert LuurtsemaAren van Waarde

Abstract

P-glycoprotein (P-gp) is a drug efflux transporter with broad substrate specificity localized in the blood-brain barrier and in several peripheral organs. In order to understand the role of P-gp in physiological and patho-physiological conditions, several carbon-11 labelled P-gp tracers have been developed and validated. This review provides an overview of the spectrum of radiopharmaceuticals that is available for this purpose. A short overview of the physiology of the blood-brain barrier in health and disease is also provided. Tracer kinetic modelling for quantitative analysis of P-gp function and expression is highlighted, and the advantages and disadvantages of the various tracers are discussed.

Citations

Dec 22, 2012·Leukemia Research and Treatment·Gabriela Nestal de MoraesRaquel Ciuvalschi Maia
Feb 21, 2013·ACS Chemical Neuroscience·Stina Syvänen, Jonas Eriksson
Apr 2, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Cristina BolzatiNicola Antonio Colabufo
Feb 18, 2016·International Journal of Biomedical Imaging·Abishek Arora, Neeta Bhagat
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