Carbon Adsorbents With Dual Porosity for Efficient Removal of Uremic Toxins and Cytokines from Human Plasma

Scientific Reports
Denys PavlenkoDimitrios Stamatialis

Abstract

The number of patients with chronic kidney disease increases while the number of available donor organs stays at approximately the same level. Unavoidable accumulation of the uremic toxins and cytokines for these patients comes as the result of malfunctioning kidneys and their high levels in the blood result in high morbidity and mortality. Unfortunately, the existing methods, like hemodialysis and hemofiltration, provide only partial removal of uremic toxins and/or cytokines from patients' blood. Consequently, there is an increasing need for the development of the extracorporeal treatments which will enable removal of broad spectrum of uremic toxins that are usually removed by healthy kidneys. Therefore, in this work we developed and tested ordered mesoporous carbons as new sorbents with dual porosity (micro/meso) that provide selective and efficient removal of a broad range of uremic toxins from human plasma. The new sorbents, CMK-3 are developed by nanocasting methods and have two distinct pore domains, i.e. micropores and mesopores, therefore show high adsorption capacity towards small water soluble toxins (creatinine), protein-bound molecules (indoxyl sulfate and hippuric acid), middle molecules (β-2-microglobulin) and cyt...Continue Reading

References

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Nov 28, 2012·Advanced Healthcare Materials·Volker PresserYury Gogotsi
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Jul 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christina KaravasiliDimitrios G Fatouros

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Citations

Sep 20, 2018·Advanced Healthcare Materials·Cécile LegallaisDimitrios Stamatialis
May 10, 2020·Nature Reviews. Nephrology·Rosalinde Masereeuw, Marianne C Verhaar
Apr 7, 2020·British Journal of Pharmacology·Feby SaviraBing H Wang
Jul 7, 2019·Toxins·Marieke SternkopfUNKNOWN European Uremic Toxin Work Group-EUTox
Nov 3, 2020·The International Journal of Artificial Organs·Yue ShenFeng Ding
May 1, 2021·Biology·Maaike K van GelderKarin G F Gerritsen
Feb 2, 2019·Journal of the American Chemical Society·Satoshi KatoOmar K Farha
Sep 15, 2021·ACS Applied Materials & Interfaces·Klaudia DymekPrzemysław J Jodłowski
Sep 4, 2021·Current Opinion in Nephrology and Hypertension·Bernard Canaud
Jul 9, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Mitchell H RosnerClaudio Ronco

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Methods Mentioned

BETA
membrane filtration
x-ray scattering
ELISA
Assay
Protein Assay

Software Mentioned

SPSS Statistics

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