Carbon-coated microbeads anal injection in outpatient treatment of minor fecal incontinence

Diseases of the Colon and Rectum
D F AltomareM Pescatori

Abstract

Anal bulking agents are injected to pose a stronger obstacle to the involuntary passage of feces and gas. This prospective, multicenter study was designed to evaluate the safety and efficacy of Durasphere anal injection for the treatment of fecal incontinence. Thirty-three unselected patients with incontinence (24 females; mean age, 61.5 +/- 14 (range, 22-83) years) underwent anal bulking agent submucosal injection with carbon-coated microbeads (Durasphere) in the outpatient regimen. The causes of incontinence were obstetric lesions in 18.2 percent, iatrogenic in 36.4 percent, rectal surgery in 12.1 percent, and idiopathic in 33.3 percent. Previous unsuccessful treatments for fecal incontinence included diet and drugs in 16 patients, biofeedback training in 7 patients, sacral nerve modulation in 6 patients, sphincteroplasty in 2 patients, artificial bowel sphincter in 1 patient, and PTQ macroplastique bulking agent in 1 patient. Under local anesthesia and antibiotic prophylaxis, a mean of 8.8 (range, 2-19) ml of Durasphere were injected into the submucosa by using a 1.5-inch, angled, 18-gauge needle. After a median follow-up of 20.8 (range, 10-22) months, the median Cleveland Clinic continence score decreased significantly from...Continue Reading

References

Jan 1, 1989·International Journal of Colorectal Disease·B LestarR Kerremans
Jun 1, 1995·Diseases of the Colon and Rectum·A Shafik
Jan 1, 1993·Diseases of the Colon and Rectum·J M Jorge, S D Wexner
Aug 6, 1998·The British Journal of Surgery·D KumarJ E Bland
Oct 17, 1998·Plastic and Reconstructive Surgery·C BernardiM Pescatori
Apr 27, 2005·The British Journal of Surgery·C J Vaizey, M A Kamm
Jan 6, 2007·The British Journal of Surgery·S J van der HagenC G Baeten

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Citations

May 7, 2008·Langenbeck's Archives of Surgery·Susan GalandiukQuincy J Greene
Sep 6, 2012·Updates in Surgery·Zeiad I HussainStevan Stojkovic
Mar 27, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C LuoI P Bissett
May 15, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A D BeggsA M Abulafi
Jan 11, 2014·World Journal of Gastroenterology : WJG·Julie Ann M Van Koughnett, Steven D Wexner
Dec 21, 2013·The Permanente Journal·Jennifer Y Wang, Maher A Abbas
Apr 25, 2014·Gastroenterology Report·Lorenzo Carlo Pescatori, Mario Pescatori
Mar 13, 2014·Surgical Endoscopy·Andreas M KaiserSteven D Wexner
May 10, 2013·Techniques in Coloproctology·C E Koh, M J Solomon
Feb 3, 2009·Gastrointestinal Endoscopy·David A Johnson
Feb 5, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F La Torre, F de la Portilla
Oct 4, 2011·The British Journal of Surgery·Z I HussainS G Stojkovic
Nov 18, 2009·The British Journal of Surgery·L Bartlett, Y-H Ho
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Yasuko MaedaChristine Norton
Mar 13, 2009·Diseases of the Colon and Rectum·Felix AignerUNKNOWN Coloproctology Working Group
Feb 9, 2013·Diseases of the Colon and Rectum·S MaslekarP M Sagar
Aug 10, 2011·Diseases of the Colon and Rectum·Anders MellgrenUNKNOWN SNS Study Group
Apr 20, 2012·Diseases of the Colon and Rectum·Maher A AbbasLinda J Chun
Sep 15, 2010·Deutsches Ärzteblatt International·Michael ProbstGerd Kolbert
Feb 5, 2021·Clinics in Colon and Rectal Surgery·Srinivas Joga IvaturyIan M Paquette
May 7, 2009·Current Opinion in Anaesthesiology

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