Carbon-coated stents in patients with acute coronary syndromes.

Clinical Cardiology
Jochen WöhrleMatthias Kochs

Abstract

For patients with ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI), rapid restoration of coronary blood flow is the primary therapeutic goal. Because of the acute nature of this clinical presentation, bleeding risks may not be adequately evaluated, limiting the use of drug-eluting stents, since premature discontinuation of antiplatelet therapy strongly predicts stent thrombosis. We evaluated angiographic and clinical results of non-drug-eluting carbon-coated stents. In this prospective observational study, angiographic and clinical 6-mo results of a carbon-coated stent for treatment of acute lesions in native coronary arteries were evaluated. Angiographic main outcome measures included in-stent late loss and binary restenosis rate. Major adverse cardiac events (MACEs) were defined as any death, Q-wave myocardial infarction (MI), and target lesion revascularization. We included 320 patients with STEMI (n = 205) or NSTEMI (n = 115) with 360 lesions. Reference vessel diameter was 2.93 +/- 0.53 mm and stented length 22.7 +/- 13.8 mm. Angiographic follow-up was available in 220 of 360 lesions (61%). In-stent late loss was 0.69 +/- 0.75 mm, with a binary restenosis rate of 19.1%. For the t...Continue Reading

References

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Citations

Oct 15, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Angelika RinkerJochen Wöhrle
Jul 30, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Alan M GaffneyMarek W Radomski
Apr 22, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Peter HöferHenriette Walter

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