Abstract
The effectiveness of CO2 gas as a perfusion medium was compared to that of saline in laser ablation of human atheromatous plaque. In an experimental circulation-occlusion model using flowing whole blood, human cadaveric arterial samples were irradiated by a sapphire probe with the Nd-YAG laser. The following experiments were performed: 1) lasing without perfusion, 2) lasing with saline perfusion of the probe, and 3) lasing with CO2 perfusion. Different perfusion flow rates of saline and CO2 were used. Results showed that the mean ablation area was 1.6-fold larger with CO2 than with saline perfusion (P less than 0.05, Student's t test). The mean lateral injury at the site adjacent to the ablation crater and at the area directly facing the probe was not significantly different with either perfusion medium. The larger ablation area with CO2 was probably due to the fact that CO2 is a good insulator for maintaining a higher probe temperature and keeps the probe free of blood debris. In conclusion, our results show that CO2 perfusion facilitates more effective laser ablation of atheromatous plaque than saline perfusion by the sapphire probe with the continuous wave Nd-YAG laser.
References
Jan 1, 1989·Lasers in Surgery and Medicine·S H SilvermanG S Abela
Mar 1, 1989·Investigative Radiology·J LammerE Reichel
Oct 1, 1987·Circulation·E O Feigl
Jun 1, 1986·Cardiovascular Research·T J BowkerA F Rickards
Sep 1, 1988·Radiology·J Lammer, F Karnel
Feb 1, 1988·Cardiovascular Research·E PilgerH Bertuch
Jan 1, 1988·Lasers in Surgery and Medicine·S H SilvermanJ M Seeger
Jul 1, 1986·Journal of the American College of Cardiology·G S AbelaC R Conti
Jul 1, 1986·Journal of the American College of Cardiology·B I LeeR D Fletcher
Apr 1, 1985·Journal of the American College of Cardiology·W S GrundfestT J Pacala
May 1, 1985·The American Journal of Cardiology·A FenechC R Conti
Jan 1, 1985·Lasers in Surgery and Medicine·M D KaplanD S Choy
Mar 1, 1967·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·H Burko, E C Klatte
Jan 1, 1984·Catheterization and Cardiovascular Diagnosis·L GessmanV Maranhao
May 1, 1984·Radiology·R CoffeyW B Ballinger
Aug 1, 1983·Physics in Medicine and Biology·A L McKenzie
Jul 1, 1982·AJR. American Journal of Roentgenology·I F Hawkins
Dec 1, 1982·The American Journal of Cardiology·G S AbelaC R Conti
Aug 1, 1940·Annals of Surgery·R M Moore, C W Braselton