PMID: 8938816Oct 1, 1996Paper

Carbon dioxide induced panic attack in panic disorder in Japan

Progress in Neuro-psychopharmacology & Biological Psychiatry
I SasakiI Fujii

Abstract

1. The authors investigated the psychological and biochemical factors associated with challenge by 5% CO2-95% O2 inhalation for 20 min. While fifteen healthy people were used as control, thirteen cases who were diagnosed by DSM-III-R as suffering from panic disorder were used as subjects. CO2 inhalation induced panic in 38% of the panic disorder patients, but did not cause panic in any of the control cases (0%). 2. Acute panic inventory (API), heart rate and breathing rate of the panic group increased significantly after CO2 inhalation compared with the values in the control and non-panic groups. 3. Heart rates and systolic blood pressure were significantly higher those in the panic disorder and non-panic groups than in the control group prior to CO2 inhalation. The cortisol values in the panic and non-panic groups also were significantly higher than those in the control group before and after CO2 inhalation. 4. These results suggest elevated activity of the sympathetic nervous system during panic. The significantly higher heart rate, systolic blood pressure and cortisol values of the panic disorder subjects relative to the control before CO2 inhalation may have been due to circumstantial factors. The present findings of convin...Continue Reading

References

Apr 1, 1990·Biological Psychiatry·W C Sanderson, S Wetzler
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·D J NuttC Lawson
Jun 27, 2002·Psychoneuroendocrinology·Spilios V ArgyropoulosDavid J Nutt
Aug 6, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Alicia E Meuret, Thomas Ritz
Nov 2, 2006·The International Journal of Neuropsychopharmacology·Marlies A van DuinenEric J L Griez
Oct 22, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Julio Mario Xerfan do AmaralAntonio Egidio Nardi
Aug 30, 2005·Anais Da Academia Brasileira De Ciências·Frederico G GraeffFrancisco S Guimarães
Jan 30, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertWilliam H Coryell
Sep 30, 2003·Journal of Psychopharmacology·J E BaileyD J Nutt
Dec 1, 2020·Journal of Psychiatric Research·Umit Tural, Dan V Iosifescu

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