Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial

Cancer Communications
Lin KongJiade J Lu

Abstract

Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. The particle therapy represents a new promising therapeutic approach to circumvent these prohibitive conditions with improved treatment efficacy. Patients with newly diagnosed malignant gliomas will have their tumor tissue samples submitted for the analysis of the status of O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. In Phase I, the patients will undergo an induction carbon ion radiotherapy (CIRT) boost followed by 60 GyE of proton irradiation with concurrent temozolomide (TMZ) at 75 mg/m2. To determine the maximal dose of safe induction boost, the tolerance, and acute toxicity rates in a dose-escalation manner from 9 to 18 GyE in three fractions will be used. In Phase III, GBM-only patients will be randomized to receive either 60 GyE (2 GyE per fraction) of proton irradiation with concurrent TMZ (control arm) or a CIRT boost (dose determined in Phase I of this tria...Continue Reading

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Citations

Oct 2, 2019·Journal of Neuro-oncology·Timothy D MalouffDaniel M Trifiletti
Dec 28, 2019·International Journal of Molecular Sciences·Juliette ThariatFrançois Chevalier
Mar 12, 2021·Frontiers in Oncology·Daniel K EbnerToshiyuki Shirai
Jul 27, 2021·Frontiers in Oncology·Xanthene MilesJulie Bolcaen
Sep 1, 2021·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Tae-Wook HaHyung Jun Kim
Jan 7, 2022·Biomaterials Science·Ruiqi LiJinghua Ren

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Methods Mentioned

BETA
irradiating
X-ray

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