Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma

Cancer Medicine
R ImaiWorking Group for Carbon Ion Radiotherapy for Bone and Soft Tissue Sarcomas

Abstract

Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients' median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3 . The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R H GreinerP Thum
Jul 1, 1991·Annals of Surgery·F K Storm, D M Mahvi
Oct 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J D SlaterL J Peters
Jul 30, 1994·International Journal of Radiation Oncology, Biology, Physics·C N CattonV Fornasier
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·J LeVayI Quirt
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Jul 3, 1999·World Journal of Surgery·M MalerbaF Crucitti
Sep 24, 2002·International Journal of Radiation Oncology, Biology, Physics·Emad YoussefEdgar Ben-Josef
Mar 17, 2004·Clinical Orthopaedics and Related Research·Noriyoshi KawaguchiYasushi Matsushita
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Lucyna KepkaSaveli I Goldberg
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Thomas F DelaneyHerman D Suit
May 27, 2009·International Journal of Radiation Oncology, Biology, Physics·Itsuko SerizawaHirohiko Tsujii
Jun 5, 2014·Cancer·Patrick W O'DonnellJay S Wunder
Feb 2, 2015·The Lancet Oncology·Tadashi KamadaWilliam T Chu
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Reiko ImaiUNKNOWN Working Group for Bone and Soft Tissue Sarcomas

❮ Previous
Next ❯

Citations

Feb 12, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Aleksandra SobiborowiczPiotr Rutkowski
Mar 12, 2021·Frontiers in Oncology·Daniel K EbnerToshiyuki Shirai
Jun 28, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung Su Kim, Hong-Gyun Wu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Prism
SPSS
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Anticancer Research
R ImaiWORKING GROUP FOR BONE and SOFT-TISSUE SARCOMAS
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
T KamadaWorking Group for the Bone and Soft Tissue Sarcomas
International Journal of Radiation Oncology, Biology, Physics
Itsuko SerizawaH Tsujii
© 2022 Meta ULC. All rights reserved