Carbon monoxide and bilirubin production in neonates

Seminars in Perinatology
D K StevensonChristopher H Contag

Abstract

Neonatal hyperbilirubinemia is a normal postnatal phenomenon resulting from a transitional imbalance between the production and elimination of bilirubin in the neonate. Bilirubin has been shown to be not only a potent antioxidant, but also toxic at excessive concentrations. As a result, the biology of bilirubin, its production, regulation, and measurements have been the focus of extensive studies. Bilirubin, carbon monoxide, and iron are derived from the degradation of heme, a ubiquitous two-step pathway catalyzed by the enzyme, heme oxygenase. It has been shown that these metabolically active products from the heme catabolic pathway may, in turn, influence many other biologic processes. This report provides a brief overview of these interrelationships in the hope that it may provide insight into the central role this pathway plays in the existence of most organisms.

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Citations

Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·C M Harrison, C C Andersen
Jan 27, 2011·Audiology & Neuro-otology·Anthony T Cacace, Joaquim M B Pinheiro
Oct 9, 2008·Canadian Journal of Physiology and Pharmacology·Takeshi MorisawaDavid K Stevenson
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Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael Kaplan, Cathy Hammerman
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Apr 20, 2005·Neonatal Network : NN·Linda J Juretschke
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael KaplanMaurizio Muraca
Jul 20, 2019·Fetal and Pediatric Pathology·Birol Karabulut, Baran Cengiz Arcagok
Nov 20, 2002·World Journal of Gastroenterology : WJG·Zhen-Wei XiaShan-Chang Yu
Jun 12, 2003·Chemical Reviews·Christophe Colas, Paul R Ortiz de Montellano

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