Carbon monoxide and biliverdin suppress bovine viral diarrhoea virus replication

The Journal of General Virology
Zhiqian MaShuqi Xiao

Abstract

Bovine viral diarrhoea virus (BVDV) causes significant economic losses to the cattle industry worldwide. Previously, we demonstrated that heme oxygenase-1 (HO-1) can inhibit BVDV replication via an unknown molecular mechanism. To elucidate the mechanism involved, we assess whether the HO-1 downstream metabolites carbon monoxide (CO), biliverdin (BV) and iron affect BVDV replication. We treated Madin-Darby bovine kidney (MDBK) cells with an exogenous CO donor, CORM-2. We found that CORM-2 but not its inactive form (iCORM-2) inhibited BVDV replication in a dose-dependent and time duration-dependent manner, suggesting a CO-specific mediation of the CORM-2 antiviral effect. Direct incubation of BVDV with high-dose CORM-2 reduced virus titres, suggesting that CORM-2 attenuates BVDV growth by both physically inactivating virus particles in the extracellular environment and affecting intracellular BVDV replication, but mainly via an intracellular mechanism. Exogenous BV treatment, both post-infection and co-incubation with BVDV, inhibited BVDV replication in a dose-dependent manner, indicating that BV has potent antiviral activity against BVDV. Direct incubation of BVDV with BV had no significant effect on virus titres, indicating tha...Continue Reading

References

Jul 1, 1991·Japanese Journal of Cancer Research : Gann·H MoriS Taji
Jul 15, 1997·European Journal of Biochemistry·W K McCoubreyM D Maines
Jan 8, 2005·The Journal of Biological Chemistry·Carine FillebeenKostas Pantopoulos
Jan 15, 2005·Antioxidants & Redox Signaling·Stefan W Ryter, Augustine M K Choi
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Krishnakumar Devadas, Subhash Dhawan
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Kazuhisa YuasaMasatomo Mori
Dec 7, 2007·The Journal of Clinical Investigation·Su Wol ChungMark A Perrella
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhaowen ZhuWarren N Schmidt
Nov 20, 2008·Cellular Microbiology·Su Wol ChungMark A Perrella
Sep 25, 2009·World Journal of Gastroenterology : WJG·Wei-Hong HouHerbert-L Bonkovsky
Oct 17, 2009·Veterinary Microbiology·Hana Van Campen
Jan 2, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabeth LehmannGabriele Sass
Nov 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhaowen ZhuWarren N Schmidt
May 23, 2012·Veterinary Microbiology·Yu DengGuang-Zhi Tong
Jan 16, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adam ChernickFrank van der Meer
Oct 30, 2015·Scientific Reports·Chong ZhangShuqi Xiao
Aug 25, 2016·Scientific Reports·Chin-Kai TsengJin-Ching Lee

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Citations

Apr 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yu-Chieh SuJin-Ching Lee
Apr 2, 2020·Frontiers in Microbiology·Angke ZhangGaiping Zhang

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