Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform

Free Radical Biology & Medicine
Laura Conde de la RosaHan Moshage

Abstract

Most chronic liver diseases are accompanied by oxidative stress, which may induce apoptosis in hepatocytes and liver injury. Oxidative stress induces heme oxygenase-1 (HO-1) expression. This stress-responsive cytoprotective protein is responsible for heme degradation into carbon monoxide (CO), free iron, and biliverdin. CO is an important intracellular messenger; however, the exact mechanisms responsible for its cytoprotective effect are not yet elucidated. Thus, we investigated whether HO-1 and CO protect primary hepatocytes against oxidative-stress-induced apoptosis. In vivo, bile duct ligation was used as model of chronic liver disease. In vitro, primary hepatocytes were exposed to the superoxide anion donor menadione in a normal and in a CO-- containing atmosphere. Apoptosis was determined by measuring caspase-9, -6, -3 activity and poly(ADP-ribose) polymerase cleavage, and necrosis was determined by Sytox green staining. The results showed that (1) HO-1 is induced in chronic cholestatic liver disease, (2) superoxide anions time- and dose-dependently induce HO-1 activity, (3) HO-1 overexpression inhibits superoxide-anions-induced apoptosis, and (4) CO blocks superoxide-anions-induced JNK phosphorylation and caspase-9, -6, -...Continue Reading

References

Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H MoshageC S Lieber
Jan 15, 1993·Science·A VermaS H Snyder
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Apr 16, 1998·Cell Biology and Toxicology·V TurcanuP Poindron
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T A VosH Moshage
Dec 10, 1999·The Journal of Clinical Investigation·F AmersiJ W Kupiec-Weglinski
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R ThomH Ischiropoulos
Oct 4, 2000·The Journal of Experimental Medicine·S BrouardM P Soares
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Aug 28, 2001·Gastroenterology·A E Reid
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenari NagaiNeil Kaplowitz
Jul 19, 2002·Cardiovascular Research·Xiao-ming LiuWilliam Durante
Dec 10, 2002·Antioxidants & Redox Signaling·Michael Bauer, Inge Bauer
Dec 25, 2002·Free Radical Biology & Medicine·Carmela Loguercio, Alessandro Federico
Apr 1, 2003·The Journal of Biological Chemistry·Dharminder ChauhanKenneth C Anderson
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byung-Min ChoiHun-Taeg Chung
May 2, 2003·International Review of Cytology·Anna-Liisa Nieminen
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark J CzajaYongjun Wang
Jul 15, 2003·The Journal of Biological Chemistry·Danielle MorseAugustine M K Choi
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gabriele SassGisa Tiegs
Dec 6, 2003·The Journal of Experimental Medicine·Brian S ZuckerbraunLeo E Otterbein
Mar 24, 2004·Free Radical Biology & Medicine·Pengfei GongNatalia Nieto
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marieke H SchoemakerHan Moshage
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gabriele SassGisa Tiegs
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Stefan J Riedl, Yigong Shi
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Constantino FondevilaFritz H Bach
Jul 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Signe B BlumenthalAngelika M Vollmar
Sep 13, 2005·Biochemical and Biophysical Research Communications·Tung-Yu TsuiSheung-Tat Fan
Sep 28, 2006·Journal of Biochemistry and Molecular Biology·Ebenezer Olatunde Farombi, Young Joon Surh

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Citations

Oct 7, 2009·Antioxidants & Redox Signaling·Montserrat MaríJosé C Fernández-Checa
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ji-Young HongHartmut Jaeschke
Mar 11, 2011·BMC Cell Biology·Cláudia S F QueirogaHelena L A Vieira
Apr 3, 2012·Biological & Pharmaceutical Bulletin·Toru KitanoTakashi Suzuki
Jan 1, 2013·Oxidative Medicine and Cellular Longevity·Melissa KnauertPatty J Lee
Apr 27, 2012·Biochemistry Research International·Cláudia S F QueirogaHelena L A Vieira
May 29, 2010·Mediators of Inflammation·Joseph Fomusi Ndisang
Jan 23, 2010·Annals of Medicine·Subhamay GhoshNandor Marczin
Apr 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Sandra DunningHan Moshage
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Tina E LawsonDorne R Yager
Jan 2, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabeth LehmannGabriele Sass
Jun 4, 2015·Pharmacology Research & Perspectives·Laura Conde de la RosaHan Moshage
Dec 3, 2014·Redox Biology·Jörn M Schattenberg, Mark J Czaja
Sep 30, 2016·Cell Death & Disease·Marta B AfonsoCecília M P Rodrigues
Sep 9, 2016·Physiological Reviews·Anita AyerRoland Stocker
Mar 27, 2019·Redox Report : Communications in Free Radical Research·W Alfredo Ríos-OcampoHan Moshage
Feb 5, 2009·American Journal of Physiology. Endocrinology and Metabolism·Joseph Fomusi Ndisang, Ashok Jadhav
Sep 26, 2019·Frontiers in Aging Neuroscience·Cuilin ZhangXian Zhang
Sep 4, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miguel N PintoPradip K Mascharak

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