Carbon monoxide pollution and neurodevelopment: A public health concern

Neurotoxicology and Teratology
Richard J Levy

Abstract

Although an association between air pollution and adverse systemic health effects has been known for years, the effect of pollutants on neurodevelopment has been underappreciated. Recent evidence suggests a possible link between air pollution and neurocognitive impairment and behavioral disorders in children, however, the exact nature of this relationship remains poorly understood. Infants and children are uniquely vulnerable due to the potential for exposure in both the fetal and postnatal environments during critical periods in development. Carbon monoxide (CO), a common component of indoor and outdoor air pollution, can cross the placenta to gain access to the fetal circulation and the developing brain. Thus, CO is of particular interest as a known neurotoxin and a potential public health threat. Here we review overt CO toxicity and the policies regulating CO exposure, detail the evidence suggesting a potential link between CO-associated ambient air pollution, tobacco smoke, and learning and behavioral abnormalities in children, describe the effects of subclinical CO exposure on the brain during development, and provide mechanistic insight into a potential connection between CO exposure and neurodevelopmental outcome. CO can...Continue Reading

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Citations

May 25, 2016·International Journal of Hygiene and Environmental Health·Martine VrijheidMark Nieuwenhuijsen
Sep 23, 2016·Journal of the Neurological Sciences·Şeref Kerem Çorbacıoğlu
Sep 13, 2016·Neurotoxicology and Teratology·Richard J Levy
Aug 19, 2016·Anesthesia and Analgesia·Richard J Levy
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Apr 13, 2020·Environmental Science and Pollution Research International·Daniele SofiaAristide Giuliano
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Nov 23, 2017·Environmental Health and Preventive Medicine·Geon-Woo LeeYoung-Wook Lim
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