Carbon monoxide protects the kidney through the central circadian clock and CD39

Proceedings of the National Academy of Sciences of the United States of America
Matheus Correa-CostaLeo E Otterbein

Abstract

Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ transplantation. Treatment with carbon monoxide (CO) modulates the innate immune response associated with IRI and accelerates tissue recovery. The mechanism has been primarily descriptive and ascribed to the ability of CO to influence inflammation, cell death, and repair. In a model of bilateral kidney IRI in mice, we elucidate an intricate relationship between CO and purinergic signaling involving increased CD39 ectonucleotidase expression, decreased expression of Adora1, with concomitant increased expression of Adora2a/2b. This response is linked to a >20-fold increase in expression of the circadian rhythm protein Period 2 (Per2) and a fivefold increase in serum erythropoietin (EPO), both of which contribute to abrogation of kidney IRI. CO is ineffective against IRI in Cd39 -/- and Per2 -/- mice or in the presence of a neutralizing antibody to EPO. Collectively, these data elucidate a cellular signaling mechanism whereby CO modulates purinergic responses and circadian rhythm to protect against injury. Moreover, these effects involve CD39- and adenosinergic-dependent stabilization of Per2. As CO also increases serum EPO levels in human v...Continue Reading

References

Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D K YsebaertM E De Broe
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre, Joel M Weinberg
Jan 6, 2005·American Journal of Physiology. Renal Physiology·Bellamkonda K KishoreSimon C Robson
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Trinity VeraDavid E Stec
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Aug 16, 2006·The Journal of Experimental Medicine·Brian S ZuckerbraunLeo E Otterbein
Oct 27, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joshua M Thurman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Beek Y ChinLeo E Otterbein
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arvand HaschemiLeo E Otterbein
Oct 26, 2007·Journal of Molecular and Cellular Cardiology·Theodore A KungMartin E Young
Dec 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Edith HochhauserZiv Ben-Ari
Jan 8, 2008·Journal of the American Society of Nephrology : JASN·Peter HillPatrick H Maxwell
Sep 25, 2008·Blood·Holger K EltzschigSean P Colgan
Nov 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Dylan BurgerQingping Feng
Jan 17, 2009·Current Hypertension Reports·Tambi Jarmi, Anupam Agarwal
Feb 5, 2009·The Journal of Pharmacology and Experimental Therapeutics·Steve LancelRemi Neviere
Jun 30, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hye Ryoun JangHamid Rabb
Mar 17, 2010·Cell Biochemistry and Function·Kursad GencSermin Genc
Sep 3, 2010·Nature Reviews. Drug Discovery·Roberto Motterlini, Leo E Otterbein
Oct 12, 2010·The Journal of Biological Chemistry·Kengo Moriyama, Michail V Sitkovsky
Oct 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D W HantoL E Otterbein
Jan 7, 2011·Journal of the American Society of Nephrology : JASN·Jessica D BauerleHolger K Eltzschig
Feb 4, 2011·BMC Medicine·Raj MunshiJonathan Himmelfarb
Mar 26, 2011·Journal of the American Society of Nephrology : JASN·Lisa R Stow, Michelle L Gumz
Mar 26, 2011·Journal of the American Society of Nephrology : JASN·Gang Jee KoHamid Rabb
Apr 2, 2011·The Journal of Biological Chemistry·Claude A PiantadosiHagir B Suliman
May 28, 2011·Journal of the American Society of Nephrology : JASN·Seung Hee YangYon Su Kim
Sep 2, 2011·The Journal of Clinical Investigation·Mei TranSamir M Parikh
Oct 18, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Kikumi S OzakiNoriko Murase
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Jan 13, 2012·American Journal of Physiology. Renal Physiology·Ana Carolina C Pessoa de SouzaLúcia Andrade
Feb 9, 2012·American Journal of Respiratory and Critical Care Medicine·Nancy Chou MacGarveyClaude A Piantadosi

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Citations

Feb 7, 2019·Chemical Society Reviews·Xingyue JiBinghe Wang
Aug 12, 2018·Scientific Reports·Saika MinegishiHiroaki Kitagishi
Sep 11, 2019·Cells·Hung-Chi YangDaniel Tsun-Yee Chiu
Dec 11, 2019·Medicinal Research Reviews·Xiaoxiao YangBinghe Wang
Aug 18, 2020·Medicinal Research Reviews·Xiaoxiao YangBinghe Wang
Jun 21, 2019·Antioxidants·Heather A DrummondDavid E Stec
Jul 10, 2020·Nature Reviews. Nephrology·Karen M DwyerSimon C Robson
Mar 17, 2020·Frontiers in Molecular Neuroscience·Fei ZhengYang Wang
Jan 13, 2019·Nature Reviews. Molecular Cell Biology·Hans Reinke, Gad Asher
Oct 17, 2018·International Urology and Nephrology·Lucas De Lavallaz, Carlos G Musso
Aug 14, 2019·Frontiers in Immunology·Ghee Rye LeeLeo E Otterbein
Feb 17, 2021·Nature Reviews. Drug Discovery·Wei RuanHolger K Eltzschig
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Dominik BakalarzMarcin Magierowski
Mar 31, 2021·Trends in Pharmacological Sciences·Rosalba SiracusaLeo E Otterbein
Jun 3, 2021·Journal of Clinical Medicine·David MontaigneMarc Hazzan
Jul 10, 2021·Bioorganic & Medicinal Chemistry·Ladie Kimberly De La CruzBinghe Wang
Jul 1, 2021·Cardiology and Therapy·Lyudmila Korostovtseva
Dec 16, 2020·ACS Biomaterials Science & Engineering·Xinlong ZangXuehong Chen
Oct 10, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Simon VilleUNKNOWN EKiTE Consortium

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