PMID: 11912455Mar 26, 2002Paper

Carbon monoxide relaxes the female pig urethra as effectively as nitric oxide in the presence of YC-1

The Journal of Urology
Annette SchroderKarl-Erik Andersson

Abstract

Nitric oxide (NO) and carbon monoxide (CO) have been suggested to relax smooth muscle by activating soluble guanylate cyclase (sGC), binding to the same site of the enzyme. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) (Cayman Co., Malmö, Sweden) increases the catalytic rate of sGC by binding to an allosteric site. We investigated whether YC-1 can modulate the relaxant responses of isolated urethral smooth muscle to exogenous CO, (NO) and electrical field stimulation. In spontaneously active and noradrenaline (Sigma-Aldrich Chemie GmbH, Steinheim, Germany) pre-contracted preparations of circular urethral smooth muscle from female pigs relaxant responses were evoked by electrical field stimulation before and after incubation with 10(-5) M. YC-1. The concentration-response curves for CO and NO were investigated in noradrenaline pre-contracted strips before and after incubation with YC-1. The tissue contents of cyclic 3',5'-guanosine monophosphate (cGMP) and cyclic adenosine monophosphate after electrical field stimulation, and the administration of CO or NO was investigated in the absence and presence of YC-1. YC-1 significantly increased the amplitude of the relaxations evoked by electrical field stimulation, CO and NO, ...Continue Reading

References

Jun 1, 1992·British Journal of Pharmacology·K Persson, K E Andersson
Apr 1, 1991·Acta Physiologica Scandinavica·A Garcia-PascualK E Andersson
Feb 15, 1994·European Journal of Pharmacology·S DokitaR M Weiss
Jan 1, 1994·World Journal of Urology·K E Andersson, K Persson
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Mar 10, 2001·Nature·J P StaschM Schramm

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Citations

Dec 1, 2010·Einstein·Carlos Arturo Levi D'AnconaEdson Antunes
Nov 15, 2017·Nature Reviews. Urology·Fabiola Z Mónica, Edson Antunes
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satish RattanMárcio A F De Godoy
Aug 22, 2013·Angewandte Chemie·Markus FollmannAlexander Straub
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Mar 18, 2011·Neurourology and Urodynamics·Fabíola Z MónicaEdson Antunes

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