Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in hemophilia A, hemophilia B and factor VII-deficient plasmas

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vance G NielsenJames F George

Abstract

Carbon monoxide derived from carbon monoxide releasing molecules (CORMs) has been demonstrated to enhance normal plasma thrombus speed of growth and strength in vitro. We tested the hypothesis that tricarbonyldichlororuthenium (II) dimer (CORM-2) improves the velocity of formation and strength of hemophiliac plasma thrombi as determined by thrombelastography. Plasma deficient (<1% normal activity) in factor VIII (FVIII; n = 11 individuals), factor IX (FIX; n = 5 individuals) or factor VII (FVII; n = 4 individuals) was exposed to 0 or 100 micromol CORM-2, with coagulation initiated with tissue factor. Coagulation kinetics were monitored with thrombelastography for 15 min. Paired t-tests were used to analyze FVIII-deficient plasma results; relative change was used to describe the other plasma types tested. In FVIII-deficient plasma, CORM-2 exposure significantly (P < 0.05) increased the velocity of thrombus formation (84%) and strength (48%) compared with plasma not exposed to CORM-2. FXI-deficient clots demonstrated an increase in velocity of formation (63%) and strength (43%) after CORM-2 exposure. Lastly, CORM-2 exposure increased FVII-deficient plasma velocity of formation (45%) and strength (63%). CORM-2 markedly enhanced th...Continue Reading

References

Sep 24, 1990·European Journal of Biochemistry·B BrüneV Ullrich
Feb 9, 2002·Circulation Research·Roberto MotterliniColin J Green
Nov 1, 2005·Expert Opinion on Investigational Drugs·Roberto MotterliniRoberta Foresti
Feb 16, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·R F JohansenJ Ingerslev
Apr 12, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenEli Cohen
Nov 7, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·G YoungD J Nugent
May 1, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·H DehmelA Tiede
May 13, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Guy YoungJørgen Ingerslev
May 7, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenJames F George

❮ Previous
Next ❯

Citations

Dec 24, 2013·Thrombosis Research·Vance G Nielsen, Etheresia Pretorius
Feb 28, 2006·Blood Cells, Molecules & Diseases·Kenneth G MannSaulius Butenas
Aug 5, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen
Dec 16, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen, Shelley J George
May 8, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenJames F George
Mar 31, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenEjaz S Khan
Oct 20, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenKeith Vosseller
Dec 7, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenKeith Vosseller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vance G NielsenJames F George
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vance G NielsenJames F George
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vance G NielsenJames F George
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vance G NielsenJeffrey D Messinger
© 2022 Meta ULC. All rights reserved