Carbon nanotube-based nanocarrier loaded with ribavirin against grass carp reovirus

Antiviral Research
Bin ZhuGao-Xue Wang

Abstract

Infectious diseases of viral origin cause major aquatic production losses in different parts of the world. Because of formidable barriers for gastrointestinal tract, skin and cell, large amounts of antiviral drugs have limited therapeutic effect. In the current study, functionalized single-walled carbon nanotubes (SWCNTs) were selected as a drug carrier to carry antiviral drug for the treatment of viral diseases on fish. The results show that increasing antiviral drug (ribavirin) intake was observed by SWCNTs carrier and therapeutic dosage to kill grass carp reovirus is significantly reduced. At 12d post infection, survival rate and infection rate were 29.7% and 50.4% for naked ribavirin treatment group exposed to the highest concentration (20 mg/L); however, survival rate of 96.6% and infection rate of 9.4% were observed in 5 mg/L ribavirin-SWCNTs treatment group. In addition, the drug detention time in different organs and tissues (blood, gill, liver, muscle, kidney and intestine) was also significantly extended (about 72 h) compared with the same dosage in naked ribavirin treatment group. Moreover, the toxicity of functionalized SWCNTs in grass carp can be minimal, and physiological markers (some antioxidant enzymes activiti...Continue Reading

References

Apr 1, 1988·Antimicrobial Agents and Chemotherapy·P ToltzisJ L Patterson
Mar 1, 1996·Antiviral Research·M JashésA Sandino
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 20, 2002·Virology·Jason D Graci, Craig E Cameron
Jan 15, 2005·Virus Research·William B Parker
May 24, 2005·Journal of the American Society for Mass Spectrometry·Chensong PanBaochuan Guo
Oct 8, 2005·Science·Diana SpieringsDouglas R Green
Jan 18, 2006·Seminars in Hematology·James L M Ferrara, Pavan Reddy
Jun 16, 2007·Journal of the American Chemical Society·Rodney P FeazellStephen J Lippard
Jul 16, 2008·Journal of Molecular Biology·Lingpeng ChengZ Hong Zhou
Oct 23, 2008·Marine Biotechnology·Mudagandur S Shekhar, Yuanan Lu
Jul 6, 2010·Journal of Virological Methods·Lanlan ZhangYaping Wang
Jun 10, 2011·Journal of Virology·Andrea Rivas-AravenaEugenio Spencer
Oct 4, 2012·Nano Letters·Chia-Hsuan WuJohn Marshall
Dec 4, 2012·Fish & Shellfish Immunology·Renyu XueChengliang Gong

❮ Previous
Next ❯

Citations

Nov 12, 2016·Fish & Shellfish Immunology·Danny Morick, Amijai Saragovi
Sep 4, 2020·ChemPlusChem·Lili LiangGrzegorz Lisak
Oct 26, 2018·International Journal of Molecular Sciences·Ding-Ping BaiXi-Feng Zhang
Apr 25, 2020·Nanomaterials·Maria Chiara SportelliNicola Cioffi
Sep 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parichehr Hassanzadeh
Jul 3, 2021·Membranes·Abayomi Babatunde AlayandeEuntae Yang
Jul 16, 2020·ACS Nano·Giacomo ReinaAlberto Bianco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.