PMID: 7090007Apr 1, 1982Paper

Carbon tetrachloride-mediated expiration of pentane and chloroform by the intact rat: the effects of pretreatment with diethyl maleate, SKF-525A and phenobarbital

Toxicology Letters
M M BechtoldA L Tappel


Measurements were made of pentane, a produce of lipid peroxidation, and chloroform (CHCl3), a product of the reproductive metabolism of carbon tetrachloride (CCl4), expired by rats administered CCl4 plus either phenobarbital (PB), 2-diethylaminoethyl-2,2-diphenyl valerate hydrochloride (SKF-525A), or diethyl maleate (DEM). In rats fed a standard laboratory diet, treatment with PB prior to injection of CCl4 increased expiration of both CHCl3 and pentane. SKF-525A pretreatment decreased the metabolism of CCl4 and CCl4-induced lipid peroxidation. DEM, a depleter of intracellular glutathione, increased lipid peroxidation. In rats fed 10% corn oil diets that contained either 0 or 40 IU of dl-alpha-tocopherol acetate, oxidant stresses caused by glutathione depletion and CCl4-intoxication were found to be additive.


Jul 1, 1978·Toxicology and Applied Pharmacology·N Stacey, B G Priestly
Aug 1, 1977·Toxicology and Applied Pharmacology·D Suriyachan, A Thithapandha
Jun 30, 1979·Toxicology and Applied Pharmacology·M Sagai, A L Tappel
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·G L Plaa, H Witschi
Jan 18, 1974·Science·C A RielyM Lieberman
Apr 1, 1970·Biochemical Pharmacology·E Boyland, L F Chasseaud


Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Mary K ManibusanDavid A Eastmond

Related Concepts

Diethyl maleate
Carbon Tetrachloride
Drug Interactions
Reduced Glutathione
Lipid Peroxides

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