Carbon tetrachloride metabolism in partially hepatectomized and sham-operated rats pre-exposed to chlordecone (Kepone).

Journal of Biochemical Toxicology
R A Young, H M Mehendale

Abstract

The potentiation of CCl4 toxicity by pre-exposure to chlordecone (CD) is well established. Chlordecone-induced metabolism of CCl4 and suppressed hepatocellular repair have been offered as possible mechanisms for this potentiation. Recent work using the partially hepatectomized (PH) rat as a model for an actively regenerating liver has provided supportive evidence for the latter hypothesis. The present study was initiated to determine if metabolism and disposition of 14CC14 is altered in the PH rat, and if this is a contributing factor to the reported protective effect afforded by the PH procedure. Male Sprague-Dawley rats (150-175 g) maintained on dietary CD (10 ppm) for 15 days were partially hepatectomized or sham-operated (SH) on day 15. Another group of CD-pretreated rats received 0.9% CoCl2 (60 mg/kg, sc, qd for 2 days) in lieu of the surgical procedure. On day 16 the rats were challenged with a single dose of CCl4 (100 microL/kg, ip) containing 20 muCi 14CCl4. A radiolabel inventory consisting of exhaled 14CCl4, 14CO2 production, total hepatic 14C, free 14CCl4 and covalently bound 14C was taken over a 6-hr time period. Lipid peroxidation and serum enzyme activities [aspartate aminotransferase (AST) and alanine aminotransf...Continue Reading

References

Apr 1, 1988·Toxicology and Applied Pharmacology·H M Mehendale, J S Klingensmith
Jan 1, 1987·Journal of Biochemical Toxicology·J A DolakR O Recknagel
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Citations

Jan 1, 1993·Archives of Toxicology·V C Rao, H M Mehendale
Mar 1, 1991·Journal of Toxicology and Environmental Health·S Chaudhury, H M Mehendale
Oct 1, 1991·Journal of Toxicology and Environmental Health·D DesaiahB S Sekhon
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·G L Plaa
Jan 1, 1989·Toxicologic Pathology·P R KodavantiH M Mehendale
Mar 15, 1991·Toxicology and Applied Pharmacology·M G Soni, H M Mehendale

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