Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1

Bioorganic & Medicinal Chemistry Letters
Andrea Scozzafava, Claudiu T Supuran

Abstract

Di-/tri- and especially tetrapeptides incorporating the sequence DADD present in the carboxyterminal region of the bicarbonate/chloride anion exchanger AE1 strongly activate human carbonic anhydrase (CA) isozyme II, whereas they act as more inefficient activators of isozymes I and IV. This discovery suggests that in the metabolon hCA II-AE1, the last protein plays a role both as a CA activator as well as a bicarbonate transporter. A synthesis of the tripeptide DAD and the tetrapeptide DADD is also presented together with the possible explanation why such highly acidic oligopeptides efficiently bind to hCA II but not to the closely related isozymes I and IV.

References

Jul 1, 1984·Archives of Gerontology and Geriatrics·W Meier-RugeK Reichlmeier
Jun 1, 1994·Journal of Pharmaceutical Sciences·B W Clare, C T Supuran
Aug 18, 1999·Bioorganic & Medicinal Chemistry Letters·F BrigantiC T Supuran
Mar 4, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A Scozzafava, C T Supuran
May 19, 2001·Blood Cells, Molecules & Diseases·R A Reithmeier

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Citations

Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran
Feb 2, 2010·Biological & Pharmaceutical Bulletin·Ayako SugimotoYukio Ono
Dec 25, 2015·Archives of Physiology and Biochemistry·Sermet YildirmisAhmet Mentese
Oct 2, 2014·IUBMB Life·Kumari Alka, Joseph R Casey
Nov 2, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Erol LicsandruClaudiu T Supuran
Dec 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adriano MollicaClaudiu T Supuran
Dec 13, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrea AngeliClaudiu T Supuran
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan M Pelis, J Larry Renfro
Mar 15, 2005·Molecular Membrane Biology·Patricio E MorganJoseph R Casey
Oct 27, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Heather L McMurtrieJoseph R Casey
Oct 27, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Silvia PastorekovaClaudiu T Supuran
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Deborah SterlingJoseph R Casey
Feb 27, 2018·Future Medicinal Chemistry·Claudiu T Supuran
Aug 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan M PelisJ Larry Renfro
Jun 10, 2008·The Journal of Biological Chemistry·Holger M Becker, Joachim W Deitmer
Sep 25, 2007·The Journal of Biological Chemistry·Mireya Gonzalez-BegneJames E Melvin
Jul 22, 2006·The Journal of Experimental Biology·Martin Grosell
Jul 28, 2006·Bioorganic & Medicinal Chemistry Letters·Claudia TemperiniClaudiu T Supuran
Dec 19, 2006·Bioorganic & Medicinal Chemistry Letters·Daniela VulloClaudiu T Supuran

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